Skip to main content
Fig. 4 | BMC Biology

Fig. 4

From: A mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis

Fig. 4

Reduced in vivo homing of β7-F185A lymphocytes to the GALT. In vivo competitive homing of splenic lymphocytes from WT mice and KI (a) or KO (b) or +/− mice (c). The ratio of KI, KO, or +/− lymphocytes over WT lymphocytes that homed to specific tissues was determined 18 h after injection. SP, spleen; PB, peripheral blood; PLN, peripheral lymph node; MLN, mesenteric lymph node; PP, Peyer’s patch; SI, small intestine; BM, bone marrow; LIV, liver; LUN, lung. ***P < 0.001; ns, not significant (Student’s t test). Data are mean ± s.d. of at least 3 independent experiments

Back to article page