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Fig. 1 | BMC Biology

Fig. 1

From: New targeted approaches for epigenetic age predictions

Fig. 1

Selection of age-associated CpGs and targeted analysis with pyrosequencing. a Illumina BeadChip profiles of 973 blood samples of 7 studies (all 450 k) were used to select age-associated CpGs by Pearson’s correlation (blue), Spearman’s rank correlation (red), or Pearson’s correlation after logarithmic transformation of age (green). Sixty-five CpGs passed at least one of these thresholds (correlation coefficient: R > 0.5 or R < − 0.5) and the Venn diagram depicts a very high overlap. b, c A multivariable linear model for these 65 age-related CpGs revealed high correlation with chronological age in the training set (b; n = 973), and in an independent validation set (c; n = 3674; color code corresponds to different studies as indicated in Supplementary Fig. S3A). d, e Epigenetic age prediction based on pyrosequencing of 6 CpGs (d) and 9 CpGs (e) in blood samples of the training set (n = 40; blue) and an independent validation set (n = 40; red)

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