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Fig. 9 | BMC Biology

Fig. 9

From: Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets

Fig. 9

Phenotype analysis of CRISPR/Cas9 generated null mice for determining the contraceptive potential of the selected genes. Spint4/5 and Ces5a null mice show significant fertility defects; meanwhile, Spint3, Pp2d1, and Saxo1 null mice appear normal. Fertility (ac), body and reproductive organ weights (df), and sperm parameters (gi) were all measured between knockout (−/−) and littermate control [wild-type (+/+) and heterozygous (+/−)] mice as indicated. Bars represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.005. ns, not significant.

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