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Fig. 4 | BMC Biology

Fig. 4

From: Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses

Fig. 4

Facets of the protein homeostasis network are upregulated in multiple aneuploid strains. a GO term enrichment analysis with Bonferroni correction applied to genes residing on nonduplicated chromosomes that had at least 1.5-fold (0.585 log2 fold change) increase in ribosome-protected footprint (FP) levels relative to wild type (WT) for each strain. The columns labeled with _1 and _2 indicate respective biological replicates of a given strain. p values were calculated from hypergeometric tests following enrichment of GO terms relating to GO Biological Process Classification obtained at http://funspec.med.utoronto.ca/. b Relative mRNA and FP levels in aneuploid strains compared to the WT cells of individual nonduplicated gene members belonging to the ribosome biogenesis GO term annotation 0042254. Each gene is represented by a dot with a black bar indicating the mean. c Relative mRNA and FP levels in aneuploid strains compared to the WT cells of individual nonduplicated gene members belonging to the 19/22S proteasome regulator and 20S proteasome complex. Each gene is represented by a dot with a black bar indicating the mean. The following figure supplements are available for Fig. 4: Additional file 9: Fig. S6, Additional file 10: Fig. S7 and Additional file 11: Table S4

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