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Fig. 6 | BMC Biology

Fig. 6

From: Suprachiasmatic nucleus-dependent and independent outputs driving rhythmic activity in hypothalamic and thalamic neurons

Fig. 6

SCN-independent neuronal rhythms in subsets of hypothalamic and ventral thalamic neurons. a Proportions of rhythmic neurons detected in ex vivo recordings for the SPZ, PVN and ventral thalamus in slices lacking (n = 51/78, 58/84 and 75/120 respectively) and containing the SCN (n = 169/198, 231/259 and 236/283 respectively). b Mean ± SEM width of firing rate peak for neurons isolated from SCN target regions in slices lacking or containing the SCN. Data analysed by mixed-effects linear model (SCN: F1,46 = 8.63, P = 0.005; region: F2,631 = 0.65, P = 0.52; interaction: F2,631 = 0.56, P = 0.57). ce Representative spontaneous firing profiles recorded from SPZ (c), PVN (d) and ventral thalamus (e) from slices prepared during early or late day and containing or lacking the SCN. Neurons that did not meet criteria for rhythmicity (see the “Methods” section) indicated by #. fh Mean ± SEM normalised and peak aligned firing rate profiles for rhythmic neurons from SPZ (f), PVN (g) and ventral thalamus (h) in slices containing or lacking and SCN. Raw data values used for statistical analysis can be found in Additional file 8.

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