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Fig. 4 | BMC Biology

Fig. 4

From: The transcriptional trajectories of pluripotency and differentiation comprise genes with antithetical architecture and repetitive-element content

Fig. 4

Pyknon content and density biases in gene expression changes during preimplantation development. The results in this figure are from the differential expression analysis of the human embryos from the Xie et al. study of Fig. 1a. a Venn diagram of the number of distinct pyknons within the exons of human genes that are up-regulated, down-regulated or non-differentially expressed in the blastocyst compared to the zygote. b Number of instances (shown as mean ± standard error) of pyknons per 1000 base pairs in the exons or introns of up-regulated and down-regulated genes. The pyknons in this analysis are from the unique portions of the Venn diagram of a. Asterisk indicates statistical significance (P values < 0.05; Mann-Whitney U test). c Barplots showing the percentage of pyknons that overlap with repetitive elements on the whole genome. The asterisks indicate that statistically significant differences exist between the distribution of pyknons of the intersection in repetitive elements in comparison to all three (up-regulated, down-regulated, or non-differentially expressed) of the respective distributions of pyknons that are unique in each gene set (P value < 10−5; chi-squared test)

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