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Table 3 Comparison of cancer driver variant predictors on the DRGN benchmark data sets. The last column shows the AUC drop with respect the EXPDRV+ALL data set in Table 2

From: Current cancer driver variant predictors learn to recognize driver genes instead of functional variants

Method

AUC

AUPRC

AUC drop

ParsSNP

59.4

52.0

27.5

CanDrA v+

66.2

64.7

20.9

Chasm 3.1

76.6

74.1

14.5

CHASMplus

72.3

69.8

22.0

FATHMM

69.1

65.9

21.9

TransFIC

59.6

53.0

8.4

Condel

55.9

51.7

8.4

DEOGEN2

57.2

48.7

11.6

CADD

63.6

55.5

10.1

M-CAP

47.4

45.9

6.6

MetaSVM

55.7

49.2

11.1

Dummy

50.0

44.2

48.1