Fig. 2

Distribution of protein Pfam domains associated with apoptosis in molluscs and other metazoans. Mme, Mercenaria mercenaria; Rph, Ruditapes philippinarum; Afa, Azumapecten farreri; Mph, Modiolus philippinarum; Cvi, Crassostrea virginica; Pfu, Pinctada fucata; Csq, Chrysomallon squamiferum; Lgi, Lottia gigantea; Bgl, Biomphalaria glabrata; Aca, Aplysia californica; Adu, Architeuthis dux; Obi, Octopus bimaculoides; Cte, Capitella teleta; Hro, Helobdella robusta; Ame, Apis mellifera; Dme, Drosophila melanogaster; Hsa, Homo sapiens; Bfl, Branchiostoma floridae; Nve, Nematostella vectensis. Domain abbreviations: Bcl-2, apoptosis regulator proteins, Bcl-2 family; CARD, caspase recruitment domain; DED, death effector domain; IAP, inhibitor of apoptosis domain; NACHT, a domain found in NAIP, CIITA, HET-E and TEP1 proteins; NB-ARC, a nucleotide-binding adaptor shared by APAF-1, certain R gene products, and CED-4; TIR, toll/interleukin-l receptor domain; TNF, tumor necrosis factor; TNFR, tumor necrosis factor receptor; zf-C3HC4_3, zinc finger, C3HC4 type (RING finger). Expansion in M. mercenaria or Bivalves is indicated by a significant, corrected P value (P < 0.001), from Chi-square tests for overrepresentation, using all annotated genes as background. Color, from gray to red, indicates ranking from bottom to top