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Fig. 8 | BMC Biology

Fig. 8

From: Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment

Fig. 8

Recurrent missense mutations in pgi. a Location and frequency of mutations along the primary structure. Circles represent alleles from chemostat 1, triangles represent alleles from chemostat 2, and squares represent alleles from chemostat 3. Scale bar (0–100) indicates frequency attained by a particular mutant in an experimental population. b Surface representation of a single Pgi monomer with mutations observed in two or more chemostats colored cyan, those that occurred in only one chemostat colored purple, and active site residues Glu355, His386, and Lys514 colored yellow. c Crystal structure of the Pgi dimer. Colors are as in b with the second subunit shown in translucent dark gray to highlight mutations that occur at the interface between the two subunits

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