Fig. 3
From: Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants
Chromatin interaction map in tubular cells. a Knight–Ruiz (KR) matrix-balanced interaction maps for tubular cells at 500-kb, 25-kb, and 5-kb resolution. b Upper: Schematic diagram of definition of the anchor. Bottom: three ChIP-seq signals around chromatin anchor midpoints. c Proportion of interaction types. d Transcription levels for genes interacted with different numbers enhancers. ** represents p value < 0.01. * represents p value < 0.05. e Upper: Schematic diagram of definition of nearest gene and HiChIP gene. Bottom: Transcription levels for nearest or HiChIP genes for the same enhancer. ** represents p value < 0.01. f The percentages of protein expression for nearest and HiChIP genes in kidney tubule from Human Protein atlas