Fig. 3.

Optogenetic verification of the polymer optical fibers (POFs) in vivo. A The expression of CaMKIIα-ChR2-mCherry (red) in the primary motor cortex (M1) 4 weeks after viral injection. B Representative example of electrophysiological recordings before and during optogenetic stimulation. C Neurogram in response to optogenetic stimulations (472 nm, 20 Hz, 5 ms duration). D Representative moving traces in an open field before and during optogenetic modulation. E The total distance traveled in the open field is shown (n = 7 mice, mean ± standard deviation; ***p < 0.005, paired t test)