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Fig. 8 | BMC Biology

Fig. 8

From: Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis

Fig. 8

Associations of miRNA conservation classes with miRNA cotargeting, RNA regulation, and haplo-insufficiency of target genes. A Proportions of target sites with “seed overlap” cotargeting and “neighborhood” cotargeting among the same and different miRNAs, for all conserved target sites of broadly conserved miRNAs. B Fraction of the number of species in which the indicated target sites of all broadly conserved miRNAs are conserved. C Conservation patterns of the indicated target sites across 84 vertebrate species. D Cumulative distributions of fold changes (FCs) of genes with conserved 8/7mer sites of miR-128-3p (left) and miR-148a-3p (right), according to the species number threshold of 62. P values were calculated by the one-tailed Wilcoxon rank sum test. Numbers in parentheses are the numbers of target sites. E Probability of haplo-insufficient target genes with conserved 8/7mer sites of miR-128-3p (left) and miR-148a-3p (right), according to the species number threshold of 62. P values were calculated by the one-tailed Wilcoxon rank sum test. F Summary of differences and statistics of the probability of haplo-insufficient target genes with conserved 8/7mer sites, according to the species number threshold of 62. The results of all broadly conserved miRNAs are shown. P values were calculated by the one-tailed Wilcoxon rank sum test. G Summary of the present study

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