Trait | Annotation | East Asian | European | EAS-EUR Difference | |||||
---|---|---|---|---|---|---|---|---|---|
Fold-enrichment | SE | P-value | Fold-enrichment | SE | P-value | Z score | P-value | ||
Alanine aminotransferase | B top1 | 0.855 | 0.349 | 0.983 | 2.728 | 0.614 | 0.005 | −2.652 | 0.008 |
B top2 | −13.622 | 9.421 | 0.958 | 2.159 | 0.366 | 0.001 | −1.674 | 0.094 | |
Genic | 1.237 | 0.081 | 0.002 | 1.315 | 0.034 | 2.48E−18 | −0.885 | 0.376 | |
LoF intolerant | 1.272 | 0.232 | 0.227 | 1.615 | 0.121 | 2.18E−07 | −1.311 | 0.190 | |
Albumin | B top05 | −1.971 | 2.266 | 0.718 | 3.950 | 1.484 | 0.049 | −2.186 | 0.029 |
B top1 | 1.135 | 0.675 | 0.983 | 3.158 | 0.947 | 0.024 | −1.740 | 0.082 | |
B top2 | 8.223 | 7.181 | 0.958 | 3.734 | 0.670 | 6.11E−05 | 0.622 | 0.534 | |
Genic | 1.380 | 0.092 | 1.82E−05 | 1.297 | 0.027 | 2.97E−19 | 0.866 | 0.386 | |
LoF intolerant | 1.532 | 0.284 | 0.053 | 1.648 | 0.110 | 1.59E−09 | −0.381 | 0.704 | |
Albumin/globulin ratio | B top05 | 2.151 | 2.822 | 0.718 | 4.159 | 1.164 | 0.006 | −0.658 | 0.511 |
B top1 | 1.597 | 0.453 | 0.849 | 2.719 | 0.597 | 0.004 | −1.498 | 0.134 | |
B top2 | 1.794 | 1.880 | 0.953 | 2.943 | 0.632 | 0.002 | −0.579 | 0.563 | |
Genic | 1.437 | 0.079 | 1.35E−09 | 1.310 | 0.030 | 2.07E−16 | 1.502 | 0.133 | |
LoF intolerant | 2.056 | 0.283 | 5.44E−05 | 1.661 | 0.117 | 3.37E−09 | 1.294 | 0.196 | |
Aspartate aminotransferase | B top05 | −1.507 | 1.256 | 0.718 | 3.323 | 1.120 | 0.033 | −2.870 | 0.004 |
B top1 | 2.930 | 2.220 | 0.983 | 2.985 | 0.647 | 0.002 | −0.024 | 0.981 | |
B top2 | −12.232 | 6.942 | 0.958 | 2.742 | 0.496 | 0.000285 | −2.152 | 0.031 | |
Genic | 1.287 | 0.067 | 2.26E−06 | 1.314 | 0.030 | 2.39E−22 | −0.371 | 0.711 | |
LoF intolerant | 1.503 | 0.213 | 0.010 | 1.596 | 0.120 | 7.26E−08 | −0.381 | 0.703 | |
Asthma | B top05 | −2.439 | 3.102 | 0.950 | 2.329 | 0.629 | 0.034 | −1.506 | 0.132 |
B top1 | 3.842 | 2.358 | 0.983 | 2.486 | 0.524 | 0.004 | 0.561 | 0.575 | |
B top2 | −8.241 | 1.204 | 0.961 | 2.096 | 0.459 | 0.016 | −8.020 | 1.06E−15 | |
Genic | 1.008 | 0.085 | 0.928 | 1.123 | 0.040 | 0.001 | −1.235 | 0.217 | |
LoF intolerant | 0.869 | 0.236 | 0.575 | 1.223 | 0.095 | 0.016 | −1.394 | 0.163 | |
Blood sugar | B top2 | −1.152 | 1.446 | 0.953 | 2.446 | 0.533 | 0.003 | −2.334 | 0.020 |
Genic | 1.368 | 0.089 | 2.51E−05 | 1.293 | 0.065 | 2.09E−09 | 0.682 | 0.495 | |
LoF intolerant | 1.324 | 0.274 | 0.217 | 1.635 | 0.192 | 2.06E−04 | −0.930 | 0.352 | |
Blood urea nitrogen | Genic | 1.237 | 0.073 | 3.28E−04 | NA | NA | NA | NA | NA |
LoF intolerant | 1.471 | 0.238 | 0.043 | NA | NA | NA | NA | NA | |
Body mass index | Genic | 1.167 | 0.065 | 0.007 | 1.125 | 0.017 | 7.18E−12 | 0.628 | 0.530 |
LoF intolerant | 2.086 | 0.236 | 2.05E−07 | 1.682 | 0.069 | 1.46E−20 | 1.643 | 0.100 | |
Chloride | Genic | 1.361 | 0.105 | 3.80E−05 | NA | NA | NA | NA | NA |
LoF intolerant | 1.722 | 0.338 | 0.019 | NA | NA | NA | NA | NA | |
Coronary artery disease | B top05 | 1.338 | 1.226 | 0.718 | 3.230 | 0.968 | 0.020 | −1.211 | 0.226 |
B top2 | 1.051 | 1.058 | 0.953 | 2.400 | 0.473 | 0.002 | −1.164 | 0.244 | |
Denisovan | 1.691 | 0.877 | 0.003 | 2.149 | 1.522 | 0.449 | −0.261 | 0.794 | |
Genic | 1.232 | 0.047 | 5.47E−08 | 1.250 | 0.040 | 1.48E−09 | −0.282 | 0.778 | |
LoF intolerant | 1.575 | 0.181 | 3.36E−04 | 1.681 | 0.141 | 3.07E−07 | −0.460 | 0.645 | |
Diastolic blood pressure | B top05 | 2.871 | 2.759 | 0.718 | 2.907 | 0.913 | 0.039 | −0.012 | 0.990 |
B top1 | 1.124 | 0.341 | 0.983 | 2.532 | 0.479 | 0.001 | −2.394 | 0.017 | |
B top2 | 3.116 | 1.191 | 0.958 | 2.323 | 0.298 | 9.33E−06 | 0.646 | 0.519 | |
Genic | 1.271 | 0.084 | 3.07E−04 | 1.230 | 0.024 | 5.69E−18 | 0.472 | 0.637 | |
LoF intolerant | 2.050 | 0.288 | 5E−05 | 1.751 | 0.093 | 4.46E−15 | 0.988 | 0.323 | |
Estimated glomerular filtration rate | B top05 | 1.234 | 1.484 | 0.718 | 4.724 | 1.209 | 0.002 | −1.823 | 0.068 |
B top1 | 2.184 | 0.471 | 0.983 | 3.960 | 0.848 | 4.97E−04 | −1.830 | 0.067 | |
B top2 | 9.394 | 6.212 | 0.006 | 2.955 | 0.444 | 8.23E−06 | 1.034 | 0.301 | |
Genic | 1.277 | 0.050 | 1.33E−08 | 1.306 | 0.031 | 2.23E−21 | −0.483 | 0.629 | |
LoF intolerant | 1.931 | 0.203 | 3.96E−07 | 1.853 | 0.135 | 3.09E−09 | 0.320 | 0.749 | |
Hematocrit | Genic | 1.342 | 0.072 | 1.45E−07 | NA | NA | NA | NA | NA |
LoF intolerant | 2.193 | 0.280 | 1.99E−06 | NA | NA | NA | NA | NA | |
Hemoglobin | Genic | 1.397 | 0.092 | 2.85E−07 | NA | NA | NA | NA | NA |
LoF intolerant | 2.336 | 0.342 | 4.79E−06 | NA | NA | NA | NA | NA | |
Lymphocyte count | B top1 | 1.392 | 0.437 | 0.960 | 3.024 | 0.742 | 0.006 | −1.896 | 0.058 |
B top2 | 2.193 | 1.216 | 0.293 | 2.722 | 0.484 | 3.32E−04 | −0.404 | 0.686 | |
Genic | 1.178 | 0.079 | 0.015 | 1.316 | 0.028 | 2.70E−20 | −1.636 | 0.102 | |
LoF intolerant | 1.523 | 0.246 | 0.024 | 1.671 | 0.110 | 5.54E−09 | −0.549 | 0.583 | |
Mean arterial pressure | B top05 | 1.536 | 2.312 | 0.950 | 2.550 | 0.766 | 0.045 | −0.416 | 0.677 |
B top1 | 1.085 | 0.372 | 0.983 | 2.220 | 0.436 | 0.005 | −1.980 | 0.048 | |
B top2 | 1.833 | 1.321 | 0.958 | 2.083 | 0.280 | 7.84E−05 | −0.185 | 0.853 | |
Genic | 1.314 | 0.076 | 6.07E−06 | 1.219 | 0.024 | 2.03E−16 | 1.189 | 0.234 | |
LoF intolerant | 2.092 | 0.260 | 2.57E−06 | 1.784 | 0.096 | 7.51E−16 | 1.112 | 0.266 | |
Mean corpuscular hemoglobin | B top05 | 3.948 | 6.980 | 0.718 | 4.182 | 1.496 | 0.030 | −0.033 | 0.974 |
B top1 | 2.015 | 0.836 | 0.849 | 3.802 | 1.055 | 0.007 | −1.327 | 0.184 | |
B top2 | 2.520 | 2.993 | 0.953 | 4.056 | 0.734 | 1.64E−05 | −0.498 | 0.618 | |
Genic | 1.303 | 0.075 | 8.83E−06 | 1.348 | 0.046 | 1.19E−12 | −0.515 | 0.607 | |
LoF intolerant | 1.723 | 0.278 | 0.006 | 1.705 | 0.167 | 6.71E−06 | 0.056 | 0.955 | |
Mean corpuscular volume | B top1 | 1.893 | 0.630 | 0.849 | 3.790 | 1.064 | 0.009 | −1.534 | 0.125 |
B top2 | 3.423 | 3.146 | 0.953 | 3.715 | 0.666 | 4.42E−05 | −0.091 | 0.928 | |
Genic | 1.311 | 0.061 | 2.22E−07 | 3.715 | 0.666 | 4.42E−05 | −3.591 | 3.29E−04 | |
LoF intolerant | 1.657 | 0.243 | 0.006 | 1.699 | 0.154 | 4.14E−06 | −0.143 | 0.886 | |
Monocyte count | B top05 | 1.967 | 2.920 | 0.718 | 5.248 | 2.118 | 0.045 | −0.910 | 0.363 |
B top1 | 2.456 | 1.347 | 0.849 | 3.793 | 1.004 | 0.005 | −0.796 | 0.426 | |
B top2 | 1.348 | 0.975 | 0.013 | 2.773 | 0.628 | 0.005 | −1.228 | 0.219 | |
Genic | 1.255 | 0.086 | 0.002 | 1.318 | 0.040 | 7.53E−13 | −0.660 | 0.509 | |
LoF intolerant | 1.548 | 0.240 | 0.018 | 1.557 | 0.150 | 8.76E−05 | −0.030 | 0.976 | |
Neutrophil count | B top05 | 1.800 | 1.885 | 0.950 | 4.148 | 1.106 | 0.004 | −1.074 | 0.283 |
B top1 | 1.096 | 0.381 | 0.983 | 3.184 | 0.750 | 0.003 | −2.483 | 0.013 | |
B top2 | 4.964 | 0.986 | 0.958 | 2.751 | 0.518 | 0.001 | 1.985 | 0.047 | |
Genic | 1.235 | 0.080 | 0.002 | 1.256 | 0.025 | 3.62E−21 | −0.248 | 0.804 | |
LoF intolerant | 1.471 | 0.210 | 0.021 | 1.766 | 0.107 | 4.15E−11 | −1.255 | 0.210 | |
Non-albumin protein | B top05 | 4.440 | 5.075 | 0.718 | 4.291 | 1.014 | 0.001 | 0.029 | 0.977 |
B top1 | 1.817 | 0.620 | 0.849 | 2.675 | 0.549 | 0.002 | −1.036 | 0.300 | |
B top2 | 2.184 | 2.456 | 0.953 | 2.847 | 0.540 | 0.001 | −0.264 | 0.792 | |
Genic | 1.468 | 0.094 | 2.72E−09 | 1.315 | 0.033 | 6.72E−16 | 1.532 | 0.125 | |
LoF intolerant | 2.373 | 0.301 | 9.41E−07 | 1.714 | 0.114 | 1.57E−10 | 2.043 | 0.041 | |
Platelet count | B top1 | 3.575 | 0.375 | 0.983 | 4.781 | 1.276 | 0.004 | −0.907 | 0.364 |
B top2 | 2.644 | 0.641 | 0.958 | 3.744 | 0.586 | 6.10E−06 | −1.267 | 0.205 | |
Genic | 1.330 | 0.044 | 7.64E−12 | 1.366 | 0.026 | 7.71E−24 | −0.710 | 0.478 | |
LoF intolerant | 1.998 | 0.166 | 1.98E−08 | 1.984 | 0.142 | 5.76E−11 | 0.064 | 0.949 | |
Potassium | B top1 | 1.112 | 0.363 | 0.983 | 2.387 | 0.390 | 3.54E−04 | −2.393 | 0.017 |
B top2 | 2.507 | 1.948 | 0.958 | 2.326 | 0.292 | 2.99E−06 | 0.092 | 0.927 | |
Genic | 1.306 | 0.078 | 1.36E−05 | 1.103 | 0.032 | 0.002 | 2.425 | 0.015 | |
LoF intolerant | 1.944 | 0.284 | 5.48E−05 | 1.641 | 0.115 | 7.51E−08 | 0.992 | 0.321 | |
Pulse pressure | Genic | 1.393 | 0.094 | 3.91E−07 | NA | NA | NA | NA | NA |
LoF intolerant | 2.304 | 0.306 | 2.14E−06 | NA | NA | NA | NA | NA | |
Red blood cell count | B top05 | 1.639 | 2.885 | 0.718 | 4.790 | 1.325 | 0.004 | −0.993 | 0.321 |
B top1 | 2.173 | 0.691 | 0.849 | 3.476 | 0.724 | 0.001 | −1.303 | 0.193 | |
B top2 | 5.614 | 1.771 | 0.958 | 3.033 | 0.487 | 1.83E−05 | 1.405 | 0.160 | |
Genic | 1.353 | 0.066 | 4.87E−08 | 1.130 | 0.025 | 4.54E−07 | 3.159 | 0.002 | |
LoF intolerant | 2.077 | 0.255 | 1.00E−05 | 1.561 | 0.092 | 1.19E−09 | 1.901 | 0.057 | |
Serum creatinine | B top05 | 8.840 | 5.950 | 0.021 | 4.724 | 1.209 | 0.002 | 0.678 | 0.498 |
B top1 | 3.121 | 1.461 | 0.983 | 3.960 | 0.848 | 4.97E−04 | −0.497 | 0.619 | |
B top2 | 1.492 | 1.396 | 0.718 | 2.955 | 0.444 | 8.23E−06 | −0.998 | 0.318 | |
Genic | 1.289 | 0.052 | 7.98E−09 | 1.306 | 0.031 | 2.23E−21 | −0.277 | 0.782 | |
LoF intolerant | 1.865 | 0.194 | 9.85E−07 | 1.853 | 0.135 | 3.09E−09 | 0.050 | 0.960 | |
Smoking behaviors: Smoking initiation | Genic | 1.041 | 0.129 | 0.754 | NA | NA | NA | NA | NA |
LoF intolerant | 1.379 | 0.324 | 0.248 | NA | NA | NA | NA | NA | |
Sodium | B top05 | 3.381 | 4.513 | 0.718 | 2.171 | 0.552 | 0.036 | 0.266 | 0.790 |
B top1 | 1.362 | 0.715 | 0.983 | 1.953 | 0.329 | 0.003 | −0.750 | 0.453 | |
B top2 | −1.750 | 1.570 | 0.958 | 1.700 | 0.209 | 0.001 | −2.178 | 0.029 | |
Genic | 1.426 | 0.138 | 1.07E−04 | 1.130 | 0.025 | 4.54E−07 | 2.111 | 0.035 | |
LoF intolerant | 2.193 | 0.485 | 0.006 | 1.561 | 0.092 | 1.19E−09 | 1.283 | 0.200 | |
Systolic blood pressure | B top05 | 1.752 | 2.069 | 0.718 | 2.296 | 0.515 | 0.013 | −0.255 | 0.799 |
B top1 | 1.014 | 0.389 | 0.985 | 2.035 | 0.334 | 0.002 | −1.991 | 0.047 | |
B top2 | 3.253 | 1.345 | 0.958 | 2.055 | 0.244 | 9.62E−06 | 0.876 | 0.381 | |
Genic | 1.341 | 0.070 | 8.58E−08 | 1.234 | 0.024 | 3.92E−18 | 1.439 | 0.150 | |
LoF intolerant | 2.143 | 0.241 | 8.95E−08 | 1.795 | 0.087 | 3.96E−18 | 1.356 | 0.175 | |
Total cholesterol | B top1 | 4.831 | 2.371 | 0.983 | 4.722 | 1.431 | 0.008 | 0.039 | 0.969 |
B top2 | −7.322 | 9.190 | 0.953 | 2.873 | 0.781 | 0.012 | −1.105 | 0.269 | |
Genic | 1.359 | 0.086 | 2.71E−05 | 1.308 | 0.034 | 3.49E−13 | 0.553 | 0.580 | |
LoF intolerant | 1.287 | 0.303 | 0.308 | 1.432 | 0.174 | 0.011 | −0.414 | 0.679 | |
Total protein | B top05 | 5.388 | 5.538 | 0.718 | 4.096 | 0.826 | 2.83E−04 | 0.231 | 0.818 |
B top1 | 1.956 | 0.514 | 0.849 | 2.736 | 0.520 | 0.001 | −1.066 | 0.286 | |
B top2 | 1.610 | 1.907 | 0.953 | 2.825 | 0.405 | 5.76E−06 | −0.623 | 0.533 | |
Genic | 1.395 | 0.093 | 2.96E−07 | 1.310 | 0.027 | 5.72E−18 | 0.874 | 0.382 | |
LoF intolerant | 2.111 | 0.278 | 2.98E−05 | 1.745 | 0.129 | 1.75E−10 | 1.197 | 0.231 | |
Type 2 diabetes | B top05 | 2.218 | 1.431 | 0.718 | 2.204 | 0.501 | 0.016 | 0.009 | 0.993 |
B top1 | 1.085 | 0.292 | 0.983 | 2.109 | 0.392 | 0.005 | −2.092 | 0.036 | |
B top2 | 5.468 | 3.974 | 0.293 | 2.090 | 0.254 | 6.08E−06 | 0.848 | 0.396 | |
Genic | 1.171 | 0.034 | 8.13E−07 | 1.147 | 0.032 | 8.17E−06 | 0.523 | 0.601 | |
LoF intolerant | 1.955 | 0.179 | 1.56E−07 | 1.608 | 0.123 | 2.03E−06 | 1.596 | 0.110 | |
White blood cell count | B top05 | 5.024 | 3.190 | 0.718 | 5.029 | 1.350 | 0.003 | −0.001 | 0.999 |
B top1 | 1.200 | 0.354 | 0.983 | 3.307 | 0.666 | 0.001 | −2.793 | 0.005 | |
B top2 | −5.583 | 7.351 | 0.953 | 2.757 | 0.479 | 2.79E−04 | −1.132 | 0.258 | |
Genic | 1.340 | 0.073 | 5.24E−07 | 1.253 | 0.023 | 3.31E−23 | 1.148 | 0.251 | |
LoF intolerant | 1.728 | 0.204 | 1.59E−04 | 1.730 | 0.100 | 8.96E−12 | −0.007 | 0.995 |