Fig. 1

Comparison of eccDNA formation in M. oryzae and other organisms. A Examples of mechanisms of extrachromosomal circular DNA (eccDNA) formation. (1) eccDNA formation as a result of double-strand break repair. The blue enzyme represents several different types of DNA repair mechanisms. (2) eccDNA formation as a result of non-allelic homologous recombination (NAHR). The green boxes represent homologous sequences. (3) eccDNA formation as a result of LTR retrotransposon activity. The blue and green enzyme represents RNA polymerase, and the orange enzyme represents a reverse transcriptase (RVT). Rectangles that are partly blue and partly red represent hybrid LTRs formed from 5′ and 3′ LTRs during retrotransposition. DNA is drawn in black and RNA in gray. B Comparison of genome size and number of eccDNA forming regions for Arabidopsis thaliana [5], Oryza sativa [6], Homo sapiens [7], Saccharomyces cerevisiae [8], and Magnaporthe oryzae. The number of eccDNA forming regions is shown as called by our pipeline in an average sample. Circularome data for A. thaliana and O. sativa leaf tissue, H. sapiens muscle tissue, and S. cerevisiae deletion collection samples are shown. The organism and protein icons were created with BioRender.com