Figure 6

Model of lysosomal membrane proteins and the glycoprotein coat. Structural models of glycosylated DC-LAMP and LAMP-1 were drawn to scale. The models are based on the DC-LAMP crystal structure and a hypothetical in silico model of LAMP-1. The thickness of the glycoprotein coat was reported to range from 5 to 12 nm with an average of 8 nm. The membrane-distal, N-terminal domain of LAMP-1 may adopt other positions. Dotted lines indicate putative binding sites consisting of the flexible loop L1 and an adjacent β-hairpin (Figure 5B). A box corresponding to 120 nm² surface area was drawn around a top view of LAMP-1. Polypeptides are depicted in green and glycans in yellow.