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  1. Content type: Research article

    Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activ...

    Authors: Tomer Shlamkovich, Lidan Aharon, Dana Koslawsky, Yulia Einav and Niv Papo

    Citation: BMC Biology 2018 16:92

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  2. Content type: Research article

    Our understanding of the regulation of gene expression has benefited from the availability of high-throughput technologies that interrogate the whole genome for the binding of specific transcription factors an...

    Authors: Alberto Santos-Zavaleta, Mishael Sánchez-Pérez, Heladia Salgado, David A. Velázquez-Ramírez, Socorro Gama-Castro, Víctor H. Tierrafría, Stephen J. W. Busby, Patricia Aquino, Xin Fang, Bernhard O. Palsson, James E. Galagan and Julio Collado-Vides

    Citation: BMC Biology 2018 16:91

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  3. Content type: Research article

    Division of labor between reproductive queens and workers that perform brood care is a hallmark of insect societies. However, studies of the molecular basis of this fundamental dichotomy are limited by the fac...

    Authors: Romain Libbrecht, Peter R. Oxley and Daniel J. C. Kronauer

    Citation: BMC Biology 2018 16:89

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  4. Content type: Methodology article

    The ubiquitin-proteasome system (UPS) controls the stability, localization and/or activity of the proteome. However, the identification and characterization of complex individual ubiquitination cascades and th...

    Authors: Joanna Koszela, Nhan T. Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F. J. Ceccarelli, Frank Sicheri, Mike Tyers and Manfred Auer

    Citation: BMC Biology 2018 16:88

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  5. Content type: Research article

    The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribu...

    Authors: Jan Krefting, Miguel A. Andrade-Navarro and Jonas Ibn-Salem

    Citation: BMC Biology 2018 16:87

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  6. Content type: Research article

    The timing of action potentials (“spikes”) of cortical neurons has been shown to be aligned to the phase of low-frequency (< 10 Hz) local field potentials (LFPs) in several cortical areas. However, across the ...

    Authors: Moein Esghaei, Mohammad Reza Daliri and Stefan Treue

    Citation: BMC Biology 2018 16:86

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  7. Content type: Research article

    Membrane lipids play critical roles in the structure and function of membrane-embedded transporters. Salmonella typhimurium MelB (MelBSt) is a symporter coupling melibiose translocation with a cation (Na+, Li+, o...

    Authors: Parameswaran Hariharan, Elena Tikhonova, João Medeiros-Silva, Aike Jeucken, Mikhail V. Bogdanov, William Dowhan, Jos F. Brouwers, Markus Weingarth and Lan Guan

    Citation: BMC Biology 2018 16:85

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  8. Content type: Research article

    Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric ulcers and gas...

    Authors: Elvire Berthenet, Koji Yahara, Kaisa Thorell, Ben Pascoe, Guillaume Meric, Jane M. Mikhail, Lars Engstrand, Helena Enroth, Alain Burette, Francis Megraud, Christine Varon, John C Atherton, Sinead Smith, Thomas S. Wilkinson, Matthew D. Hitchings, Daniel Falush…

    Citation: BMC Biology 2018 16:84

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  9. Content type: Research article

    Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, ...

    Authors: Ivonne Heinze, Martin Bens, Enrico Calzia, Susanne Holtze, Oleksandr Dakhovnik, Arne Sahm, Joanna M. Kirkpatrick, Karol Szafranski, Natalie Romanov, Sai Nagender Sama, Kerstin Holzer, Stephan Singer, Maria Ermolaeva, Matthias Platzer, Thomas Hildebrandt and Alessandro Ori

    Citation: BMC Biology 2018 16:82

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  10. Content type: Research article

    Naked mole-rats (NMRs) are eusocially organized in colonies. Although breeders carry the additional metabolic load of reproduction, they are extremely long-lived and remain fertile throughout their lifespan. T...

    Authors: Martin Bens, Karol Szafranski, Susanne Holtze, Arne Sahm, Marco Groth, Hans A. Kestler, Thomas B. Hildebrandt and Matthias Platzer

    Citation: BMC Biology 2018 16:77

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  11. Content type: Research article

    The interaction between oomycete plant pathogen Phytophthora sojae and soybean is characterized by the presence of avirulence (Avr) genes in P. sojae, which encode for effectors that trigger immune responses and ...

    Authors: Geneviève Arsenault-Labrecque, Humira Sonah, Amandine Lebreton, Caroline Labbé, Geneviève Marchand, Allen Xue, François Belzile, Brian J. Knaus, Niklaus J. Grünwald and Richard R. Bélanger

    Citation: BMC Biology 2018 16:80

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  12. Content type: Research article

    Fungal plant pathogens pose major threats to crop yield and sustainable food production if they are highly adapted to their host and the local environment. Variation in gene expression contributes to phenotypi...

    Authors: Parvathy Krishnan, Lukas Meile, Clémence Plissonneau, Xin Ma, Fanny E. Hartmann, Daniel Croll, Bruce A. McDonald and Andrea Sánchez-Vallet

    Citation: BMC Biology 2018 16:78

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  13. Content type: Research article

    Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are c...

    Authors: Santiago Martínez-Lumbreras, Ewelina M. Krysztofinska, Arjun Thapaliya, Alessandro Spilotros, Dijana Matak-Vinkovic, Enrico Salvadori, Peristera Roboti, Yvonne Nyathi, Janina H. Muench, Maxie M. Roessler, Dmitri I. Svergun, Stephen High and Rivka L. Isaacson

    Citation: BMC Biology 2018 16:76

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  14. Content type: Research article

    RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies ...

    Authors: Pavitra Roychoudhury, Harshana De Silva Feelixge, Daniel Reeves, Bryan T. Mayer, Daniel Stone, Joshua T. Schiffer and Keith R. Jerome

    Citation: BMC Biology 2018 16:75

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  15. Content type: Research article

    In mammalian females, progressive activation of dormant primordial follicles in adulthood is crucial for the maintenance of the reproductive lifespan. Misregulated activation of primordial follicles leads to v...

    Authors: Hao Yan, Jiawei Zhang, Jia Wen, Yibo Wang, Wanbao Niu, Zhen Teng, Tongtong Zhao, Yanli Dai, Yan Zhang, Chao Wang, Yingying Qin, Guoliang Xia and Hua Zhang

    Citation: BMC Biology 2018 16:73

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  16. Content type: Research article

    The phenotypes of sperm are generally believed to be under the control of the diploid genotype of the male producing them rather than their own haploid genotypes, because developing spermatids share cytoplasm ...

    Authors: Richard Borowsky, Alissa Luk, Xinjian He and Rebecca S. Kim

    Citation: BMC Biology 2018 16:72

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  17. Content type: Research article

    Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs display a vast array of phenotypes that differ from their ancestors, yet mirror other domesticated animal species, a phenomenon known as the...

    Authors: Amanda L. Pendleton, Feichen Shen, Angela M. Taravella, Sarah Emery, Krishna R. Veeramah, Adam R. Boyko and Jeffrey M. Kidd

    Citation: BMC Biology 2018 16:64

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  18. Content type: Methodology article

    Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT ...

    Authors: Mandi E. Schmidt, Caodu Buren, James P. Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A. Raymond and Michael R. Hayden

    Citation: BMC Biology 2018 16:58

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  19. Content type: Research article

    The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple...

    Authors: Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop and Agnieszka Chacinska

    Citation: BMC Biology 2018 16:66

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    The Commentary to this article has been published in BMC Biology 2018 16:63

  20. Content type: Commentary

    Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al. f...

    Authors: Eva Zöller, R. Todd Alexander and Johannes M. Herrmann

    Citation: BMC Biology 2018 16:63

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    The original article was published in BMC Biology 2018 16:66

  21. Content type: Research article

    The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene–phenotype associations. While CRISPR/Cas...

    Authors: Denise G. Lanza, Angelina Gaspero, Isabel Lorenzo, Lan Liao, Ping Zheng, Ying Wang, Yu Deng, Chonghui Cheng, Chuansheng Zhang, John R. Seavitt, Francesco J. DeMayo, Jianming Xu, Mary E. Dickinson, Arthur L. Beaudet and Jason D. Heaney

    Citation: BMC Biology 2018 16:69

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  22. Content type: Research article

    Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for ge...

    Authors: Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon…

    Citation: BMC Biology 2018 16:70

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  23. Content type: Research article

    To prevent folate deficiencies, many countries supplement various foodstuffs with folic acid. This compound is a synthetic oxidised folate that differs from naturally occurring reduced folates in its metabolis...

    Authors: Claire Maynard, Ian Cummins, Jacalyn Green and David Weinkove

    Citation: BMC Biology 2018 16:67

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  24. Content type: Research article

    S2 cells are one of the most widely used Drosophila melanogaster cell lines. A series of studies has shown that they are particularly suitable for RNAi-based screens aimed at the dissection of cellular pathways, ...

    Authors: Anton Strunov, Lidiya V. Boldyreva, Evgeniya N. Andreyeva, Gera A. Pavlova, Julia V. Popova, Alena V. Razuvaeva, Alina F. Anders, Fioranna Renda, Alexey V. Pindyurin, Maurizio Gatti and Elena Kiseleva

    Citation: BMC Biology 2018 16:68

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  25. Content type: Research article

    Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through in...

    Authors: Florian A. Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann S. Gallot, Aurélie Docquier, Allan F. Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, Béatrice Chabi, Marc Francaux, François Casas, Damien Freyssenet, Jennifer Rieusset, Sophie Giorgetti-Peraldi…

    Citation: BMC Biology 2018 16:65

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  26. Content type: Research article

    Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract. Nevertheless, fu...

    Authors: Benjamin E. Mead, Jose Ordovas-Montanes, Alexandra P. Braun, Lauren E. Levy, Prerna Bhargava, Matthew J. Szucs, Dustin A. Ammendolia, Melanie A. MacMullan, Xiaolei Yin, Travis K. Hughes, Marc H. Wadsworth II, Rushdy Ahmad, Seth Rakoff-Nahoum, Steven A. Carr, Robert Langer, James J. Collins…

    Citation: BMC Biology 2018 16:62

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  27. Content type: Research article

    Hydrogen peroxide (H2O2) is generated as a by-product of metabolic reactions during oxygen use by aerobic organisms, and can be toxic or participate in signaling processes. Cells, therefore, need to be able to se...

    Authors: Alba Domènech, José Ayté, Fernando Antunes and Elena Hidalgo

    Citation: BMC Biology 2018 16:61

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  28. Content type: Research article

    Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular pr...

    Authors: Jose L. Olmos Jr, Suraj Pandey, Jose M. Martin-Garcia, George Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty…

    Citation: BMC Biology 2018 16:59

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  29. Content type: Research article

    Drosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpigh...

    Authors: Wenjing Zheng, Florentina Rus, Ana Hernandez, Ping Kang, William Goldman, Neal Silverman and Marc Tatar

    Citation: BMC Biology 2018 16:60

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  30. Content type: Commentary

    A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-...

    Authors: Allen M. Orville

    Citation: BMC Biology 2018 16:55

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  31. Content type: Methodology article

    Advances in tissue clearing and molecular labeling methods are enabling unprecedented optical access to large intact biological systems. These developments fuel the need for high-speed microscopy approaches to...

    Authors: Bianca Migliori, Malika S. Datta, Christophe Dupre, Mehmet C. Apak, Shoh Asano, Ruixuan Gao, Edward S. Boyden, Ola Hermanson, Rafael Yuste and Raju Tomer

    Citation: BMC Biology 2018 16:57

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  32. Content type: Research article

    Trichogrammatids are minute parasitoid wasps that develop within other insect eggs. They are less than half a millimeter long, smaller than some protozoans. The Trichogrammatidae are one of the earliest branch...

    Authors: Amelia R. I. Lindsey, Yogeshwar D. Kelkar, Xin Wu, Dan Sun, Ellen O. Martinson, Zhichao Yan, Paul F. Rugman-Jones, Daniel S. T. Hughes, Shwetha C. Murali, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni…

    Citation: BMC Biology 2018 16:54

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  33. Content type: Research article

    The evolutionary roots of human moral behavior are a key precondition to understanding human nature. Investigations usually start with a social dilemma and end up with a norm that can provide some insight into...

    Authors: J. Garay, S. Számadó, Z. Varga and E. Szathmáry

    Citation: BMC Biology 2018 16:53

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  34. Content type: Research article

    Sequencing-based analyses of low-biomass samples are known to be prone to misinterpretation due to the potential presence of contaminating molecules derived from laboratory reagents and environments. DNA conta...

    Authors: Anna Heintz-Buschart, Dilmurat Yusuf, Anne Kaysen, Alton Etheridge, Joëlle V. Fritz, Patrick May, Carine de Beaufort, Bimal B. Upadhyaya, Anubrata Ghosal, David J. Galas and Paul Wilmes

    Citation: BMC Biology 2018 16:52

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  35. Content type: Research article

    Regulatory T cells (Tregs) expressing the transcription factor FOXP3 are crucial mediators of self-tolerance, preventing autoimmune diseases but possibly hampering tumor rejection. Clinical manipulation of Tre...

    Authors: Angelika Schmidt, Francesco Marabita, Narsis A. Kiani, Catharina C. Gross, Henrik J. Johansson, Szabolcs Éliás, Sini Rautio, Matilda Eriksson, Sunjay Jude Fernandes, Gilad Silberberg, Ubaid Ullah, Urvashi Bhatia, Harri Lähdesmäki, Janne Lehtiö, David Gomez-Cabrero, Heinz Wiendl…

    Citation: BMC Biology 2018 16:47

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  36. Content type: Research article

    Environmental influences fluctuate throughout the life course of an organism. It is therefore important to understand how the timing of exposure impacts molecular responses. Herein, we examine the responses of...

    Authors: Amy F. Danson, Sarah J. Marzi, Robert Lowe, Michelle L. Holland and Vardhman K. Rakyan

    Citation: BMC Biology 2018 16:51

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  37. Content type: Research article

    Photosensitizing fluorescent proteins, which generate reactive oxygen species (ROS) upon light irradiation, are useful for spatiotemporal protein inactivation and cell ablation. They give us clues about protei...

    Authors: Yemima Dani Riani, Tomoki Matsuda, Kiwamu Takemoto and Takeharu Nagai

    Citation: BMC Biology 2018 16:50

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  38. Content type: Research article

    Intron retention (IR), the most prevalent alternative splicing form in plants, plays a critical role in gene expression during plant development and stress response. However, the molecular mechanisms underlyin...

    Authors: Gang Wei, Kunpeng Liu, Ting Shen, Jinlei Shi, Bing Liu, Miao Han, Maolin Peng, Haihui Fu, Yifan Song, Jun Zhu, Aiwu Dong and Ting Ni

    Citation: BMC Biology 2018 16:44

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  39. Content type: Research article

    Reliable recognition of individuals requires phenotypic identity signatures that are both individually distinctive and appropriately stable over time. Individual-specific vocalisations or visual patterning are...

    Authors: Sarah A. Roberts, Mark C. Prescott, Amanda J. Davidson, Lynn McLean, Robert J. Beynon and Jane L. Hurst

    Citation: BMC Biology 2018 16:48

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  40. Content type: Research article

    Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a critical role in this proce...

    Authors: Long Yang, Wenwen Gu, King-Ho Cheung, Lan Yan, Benjamin Chun-Kit Tong, Yuanying Jiang and Jun Yang

    Citation: BMC Biology 2018 16:46

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  41. Content type: Research article

    Fear conditioning is a form of learning essential for animal survival and used as a behavioral paradigm to study the mechanisms of learning and memory. In mammals, the amygdala plays a crucial role in fear con...

    Authors: Pradeep Lal, Hideyuki Tanabe, Maximiliano L. Suster, Deepak Ailani, Yuri Kotani, Akira Muto, Mari Itoh, Miki Iwasaki, Hironori Wada, Emre Yaksi and Koichi Kawakami

    Citation: BMC Biology 2018 16:45

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  42. Content type: Research article

    The presence of photoreceptive molecules outside the eye is widespread among animals, yet their functions in the periphery are less well understood. Marine organisms, such as annelid worms, exhibit a ‘shadow r...

    Authors: Thomas Ayers, Hisao Tsukamoto, Martin Gühmann, Vinoth Babu Veedin Rajan and Kristin Tessmar-Raible

    Citation: BMC Biology 2018 16:41

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