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  1. The accumulation of mtDNA mutations in different tissues from various mouse models has been widely studied especially in the context of mtDNA mutation-driven ageing but has been confounded by the inherent limi...

    Authors: Emilie Kristine Bagge, Noriko Fujimori-Tonou, Mie Kubota-Sakashita, Takaoki Kasahara and Tadafumi Kato

    Citation: BMC Biology 2020 18:150

    Content type: Research article

    Published on:

  2. The classical functions of the skeleton encompass locomotion, protection and mineral homeostasis. However, cell-specific gene deletions in the mouse and human genetic studies have identified the skeleton as a ...

    Authors: Karla J. Suchacki, Nicholas M. Morton, Calvin Vary, Carmen Huesa, Manisha C. Yadav, Benjamin J. Thomas, Sophie Turban, Lutz Bunger, Derek Ball, Martin E. Barrios-Llerena, Anyonya R. Guntur, Zohreh Khavandgar, William P. Cawthorn, Mathieu Ferron, Gérard Karsenty, Monzur Murshed…

    Citation: BMC Biology 2020 18:149

    Content type: Research article

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  4. How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed thi...

    Authors: Martin Schwersensky, Marianne Rooman and Fabrizio Pucci

    Citation: BMC Biology 2020 18:146

    Content type: Research article

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  5. Skeletal muscle (SkM) regenerates following injury, replacing damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects leave patients with loss of function, increased re-injury...

    Authors: J. W. Fleming, A. J. Capel, R. P. Rimington, P. Wheeler, A. N. Leonard, N. C. Bishop, O. G. Davies and M. P. Lewis

    Citation: BMC Biology 2020 18:145

    Content type: Research article

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  6. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation ...

    Authors: Sebastiaan P. van Kessel, Hiltje R. de Jong, Simon L. Winkel, Sander S. van Leeuwen, Sieger A. Nelemans, Hjalmar Permentier, Ali Keshavarzian and Sahar El Aidy

    Citation: BMC Biology 2020 18:137

    Content type: Research article

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  7. Neuroanatomical compartments of the mouse brain are identified and outlined mainly based on manual annotations of samples using features related to tissue and cellular morphology, taking advantage of publicly ...

    Authors: Gabriele Partel, Markus M. Hilscher, Giorgia Milli, Leslie Solorzano, Anna H. Klemm, Mats Nilsson and Carolina Wählby

    Citation: BMC Biology 2020 18:144

    Content type: Methodology article

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  8. The western flower thrips, Frankliniella occidentalis (Pergande), is a globally invasive pest and plant virus vector on a wide array of food, fiber, and ornamental crops. The underlying genetic mechanisms of the ...

    Authors: Dorith Rotenberg, Aaron A. Baumann, Sulley Ben-Mahmoud, Olivier Christiaens, Wannes Dermauw, Panagiotis Ioannidis, Chris G. C. Jacobs, Iris M. Vargas Jentzsch, Jonathan E. Oliver, Monica F. Poelchau, Swapna Priya Rajarapu, Derek J. Schneweis, Simon Snoeck, Clauvis N. T. Taning, Dong Wei, Shirani M. K. Widana Gamage…

    Citation: BMC Biology 2020 18:142

    Content type: Research article

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  9. ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate prote...

    Authors: Yuemin Tian, Patricia Korn, Priyanka Tripathi, Daniel Komnig, Dominik Wiemuth, Azadeh Nikouee, Arno Classen, Carsten Bolm, Björn H. Falkenburger, Bernhard Lüscher and Stefan Gründer

    Citation: BMC Biology 2020 18:143

    Content type: Research article

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  10. Enterotoxigenic Escherichia coli (ETEC) substantially contributes to the burden of diarrheal illnesses in developing countries. With the use of complementary in vitro models of the human digestive environment, TN...

    Authors: Charlène Roussel, Kim De Paepe, Wessam Galia, Jana De Bodt, Sandrine Chalancon, Françoise Leriche, Nathalie Ballet, Sylvain Denis, Monique Alric, Tom Van de Wiele and Stéphanie Blanquet-Diot

    Citation: BMC Biology 2020 18:141

    Content type: Research article

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  12. Some dinoflagellates cause harmful algal blooms, releasing toxic secondary metabolites, to the detriment of marine ecosystems and human health. Our understanding of dinoflagellate toxin biosynthesis has been h...

    Authors: Girish Beedessee, Takaaki Kubota, Asuka Arimoto, Koki Nishitsuji, Ross F. Waller, Kanako Hisata, Shinichi Yamasaki, Noriyuki Satoh, Jun’ichi Kobayashi and Eiichi Shoguchi

    Citation: BMC Biology 2020 18:139

    Content type: Research article

    Published on:

  13. Growing evidence shows that scientific collaboration plays a crucial role in transformative innovation in the life sciences. For example, contemporary drug discovery and development reflects the work of teams ...

    Authors: Feixiong Cheng, Yifang Ma, Brian Uzzi and Joseph Loscalzo

    Citation: BMC Biology 2020 18:138

    Content type: Research article

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  14. African swine fever virus (ASFV) is a most devastating pathogen affecting swine. In 2007, ASFV was introduced into Eastern Europe where it continuously circulates and recently reached Western Europe and Asia, ...

    Authors: Jan H. Forth, Leonie F. Forth, Samantha Lycett, Lesley Bell-Sakyi, Günther M. Keil, Sandra Blome, Sébastien Calvignac-Spencer, Antje Wissgott, Johannes Krause, Dirk Höper, Helge Kampen and Martin Beer

    Citation: BMC Biology 2020 18:136

    Content type: Research article

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  15. Life-history theory predicts a trade-off between investment into immune defence and other fitness-related traits. Accordingly, individuals are expected to upregulate their immune response when subjected to imm...

    Authors: M. Nystrand and D. K. Dowling

    Citation: BMC Biology 2020 18:135

    Content type: Research article

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  16. Daily variations in mammalian physiology are under control of a central clock in the suprachiasmatic nucleus (SCN). SCN timing signals are essential for coordinating cellular clocks and associated circadian va...

    Authors: Court Harding, David A. Bechtold and Timothy M. Brown

    Citation: BMC Biology 2020 18:134

    Content type: Research article

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  17. In order for aging to evolve in response to a declining strength of selection with age, a genetic architecture that allows for mutations with age-specific effects on organismal performance is required. Our und...

    Authors: Martin I. Brengdahl, Christopher M. Kimber, Phoebe Elias, Josephine Thompson and Urban Friberg

    Citation: BMC Biology 2020 18:128

    Content type: Research article

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  18. Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azit...

    Authors: Amy L. Burns, Brad E. Sleebs, Ghizal Siddiqui, Amanda E. De Paoli, Dovile Anderson, Benjamin Liffner, Richard Harvey, James G. Beeson, Darren J. Creek, Christopher D. Goodman, Geoffrey I. McFadden and Danny W. Wilson

    Citation: BMC Biology 2020 18:133

    Content type: Research article

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  19. The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and...

    Authors: Dhoyazan Azazi, Jonathan M. Mudge, Duncan T. Odom and Paul Flicek

    Citation: BMC Biology 2020 18:132

    Content type: Research article

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  20. Many favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. ...

    Authors: Jingke Xie, Xingyun Huang, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang…

    Citation: BMC Biology 2020 18:131

    Content type: Methodology article

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  21. Access to quantitative information is crucial to obtain a deeper understanding of biological systems. In addition to being low-throughput, traditional image-based analysis is mostly limited to error-prone qual...

    Authors: Sahand Saberi-Bosari, Kevin B. Flores and Adriana San-Miguel

    Citation: BMC Biology 2020 18:130

    Content type: Research article

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  22. The evolution of embryological development has long been characterized by deep conservation. In animal development, the phylotypic stage in mid-embryogenesis is more conserved than either early or late stages ...

    Authors: Jialin Liu, Michael Frochaux, Vincent Gardeux, Bart Deplancke and Marc Robinson-Rechavi

    Citation: BMC Biology 2020 18:129

    Content type: Research article

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  23. Understanding the genetic modifiers of neurodegenerative diseases can provide insight into the mechanisms underlying these disorders. Here, we examine the relationship between the motor neuron disease spinal m...

    Authors: Melissa B. Walsh, Eva Janzen, Emily Wingrove, Seyyedmohsen Hosseinibarkooie, Natalia Rodriguez Muela, Lance Davidow, Maria Dimitriadi, Erika M. Norabuena, Lee L. Rubin, Brunhilde Wirth and Anne C. Hart

    Citation: BMC Biology 2020 18:127

    Content type: Research article

    Published on:

  24. Plastid electron transport systems are essential not only for photosynthesis but also for dissipating excess reducing power and sinking excess electrons generated by various redox reactions. Although numerous ...

    Authors: Motoki Kayama, Jun-Feng Chen, Takashi Nakada, Yoshiki Nishimura, Toshiharu Shikanai, Tomonori Azuma, Hideaki Miyashita, Shinichi Takaichi, Yuichiro Kashiyama and Ryoma Kamikawa

    Citation: BMC Biology 2020 18:126

    Content type: Research article

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  25. Loss or disrupted expression of the FMR1 gene causes fragile X syndrome (FXS), the most common monogenetic form of autism in humans. Although disruptions in sensory processing are core traits of FXS and autism, t...

    Authors: Lena Constantin, Rebecca E. Poulsen, Leandro A. Scholz, Itia A. Favre-Bulle, Michael A. Taylor, Biao Sun, Geoffrey J. Goodhill, Gilles C. Vanwalleghem and Ethan K. Scott

    Citation: BMC Biology 2020 18:125

    Content type: Research article

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  26. The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend...

    Authors: Nathaniel S. Woodling, Arjunan Rajasingam, Lucy J. Minkley, Alberto Rizzo and Linda Partridge

    Citation: BMC Biology 2020 18:124

    Content type: Research article

    Published on:

  27. In a changing environment, a challenge for the brain is to flexibly guide adaptive behavior towards survival. Complex behavior and the underlying neural computations emerge from the structural components of th...

    Authors: Jiaqi Luo, Jessica M. Tan and Jess Nithianantharajah

    Citation: BMC Biology 2020 18:118

    Content type: Research article

    Published on:

  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Claude Rispe, Fabrice Legeai, Paul D. Nabity, Rosa Fernández, Arinder K. Arora, Patrice Baa-Puyoulet, Celeste R. Banfill, Leticia Bao, Miquel Barberà, Maryem Bouallègue, Anthony Bretaudeau, Jennifer A. Brisson, Federica Calevro, Pierre Capy, Olivier Catrice, Thomas Chertemps…

    Citation: BMC Biology 2020 18:123

    Content type: Correction

    Published on:

    The original article was published in BMC Biology 2020 18:90

  29. The initial step of a number of human or plant fungal infections requires active penetration of host tissue. For example, active penetration of intestinal epithelia by Candida albicans is critical for disseminati...

    Authors: Charles Puerner, Nino Kukhaleishvili, Darren Thomson, Sebastien Schaub, Xavier Noblin, Agnese Seminara, Martine Bassilana and Robert A. Arkowitz

    Citation: BMC Biology 2020 18:122

    Content type: Research article

    Published on:

  30. In cnidarians, antagonistic interactions with predators and prey are mediated by their venom, whose synthesis may be metabolically expensive. The potentially high cost of venom production has been hypothesized...

    Authors: Maria Y. Sachkova, Jason Macrander, Joachim M. Surm, Reuven Aharoni, Shelcie S. Menard-Harvey, Amy Klock, Whitney B. Leach, Adam M. Reitzel and Yehu Moran

    Citation: BMC Biology 2020 18:121

    Content type: Research article

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  31. Vertebrates are characterized by possession of hypobranchial muscles (HBMs). Cyclostomes, or modern jawless vertebrates, possess a rudimentary and superficial HBM lateral to the pharynx, whereas the HBM in jaw...

    Authors: Rie Kusakabe, Shinnosuke Higuchi, Masako Tanaka, Mitsutaka Kadota, Osamu Nishimura and Shigeru Kuratani

    Citation: BMC Biology 2020 18:120

    Content type: Research article

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  33. The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, le...

    Authors: Katherine E. Larrimore, Natalia S. Barattin-Voynova, David W. Reid and Davis T. W. Ng

    Citation: BMC Biology 2020 18:117

    Content type: Research article

    Published on:

  34. Colorectal cancer (CRC) development is generally accepted as a sequential process, with genetic mutations determining phenotypic tumor progression. However, matching genetic profiles with histological transiti...

    Authors: Soulafa Mamlouk, Tincy Simon, Laura Tomás, David C. Wedge, Alexander Arnold, Andrea Menne, David Horst, David Capper, Markus Morkel, David Posada, Christine Sers and Hendrik Bläker

    Citation: BMC Biology 2020 18:116

    Content type: Research article

    Published on:

  35. Modification of RNAs, particularly at the terminals, is critical for various essential cell processes; for example, uridylation is implicated in tumorigenesis, proliferation, stem cell maintenance, and immune ...

    Authors: Yun Wang, Chenchun Weng, Xiangyang Chen, Xufei Zhou, Xinya Huang, Yonghong Yan and Chengming Zhu

    Citation: BMC Biology 2020 18:115

    Content type: Research article

    Published on:

  36. Bacterial resistance to antibiotics is a growing health problem that is projected to cause more deaths than cancer by 2050. Consequently, novel antibiotics are urgently needed. Since more than half of the avai...

    Authors: Benedict Hew, Qiao Wen Tan, William Goh, Jonathan Wei Xiong Ng and Marek Mutwil

    Citation: BMC Biology 2020 18:114

    Content type: Research article

    Published on:

  37. Studies of mammalian sexual dimorphism have traditionally involved the measurement of selected dimensions of particular skeletal elements and use of single data-analysis procedures. Consequently, such studies ...

    Authors: Norman MacLeod and Liora Kolska Horwitz

    Citation: BMC Biology 2020 18:113

    Content type: Research article

    Published on:

  39. Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystande...

    Authors: Zhiquan Liu, Siyu Chen, Huanhuan Shan, Yingqi Jia, Mao Chen, Yuning Song, Liangxue Lai and Zhanjun Li

    Citation: BMC Biology 2020 18:111

    Content type: Research article

    Published on:

  40. To successfully invade new hosts, plant viruses must break host resistance and be competent to move within and between plant cells. As a means, viral proteins known as pathogenicity determinants have evolved t...

    Authors: Ashwin Nair, Kiran Sankar Chatterjee, Vikram Jha, Ranabir Das and P. V. Shivaprasad

    Citation: BMC Biology 2020 18:110

    Content type: Research article

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  41. Endocrine cells of the zebrafish digestive system play an important role in regulating metabolism and include pancreatic endocrine cells (PECs) clustered in the islets of Langerhans and the enteroendocrine cel...

    Authors: Arnaud Lavergne, Estefania Tarifeño-Saldivia, Justine Pirson, Anne-Sophie Reuter, Lydie Flasse, Isabelle Manfroid, Marianne L. Voz and Bernard Peers

    Citation: BMC Biology 2020 18:109

    Content type: Research article

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  42. Recent advances in sequencing have facilitated large-scale analyses of the metagenomic composition of different samples, including the environmental microbiome of air, water, and soil, as well as the microbiom...

    Authors: Judith Neukamm, Saskia Pfrengle, Martyna Molak, Alexander Seitz, Michael Francken, Partick Eppenberger, Charlotte Avanzi, Ella Reiter, Christian Urban, Beatrix Welte, Philipp W. Stockhammer, Barbara Teßmann, Alexander Herbig, Katerina Harvati, Kay Nieselt, Johannes Krause…

    Citation: BMC Biology 2020 18:108

    Content type: Research article

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  43. When stressed, eukaryotic cells produce triacylglycerol (TAG) to store nutrients and mobilize autophagy to combat internal damage. We and others previously reported that in yeast, elimination of TAG synthesizi...

    Authors: Dan Li, Shu-Gao Yang, Cheng-Wen He, Zheng-Tan Zhang, Yongheng Liang, Hui Li, Jing Zhu, Xiong Su, Qingqiu Gong and Zhiping Xie

    Citation: BMC Biology 2020 18:107

    Content type: Research article

    Published on:

  44. A major challenge in biodiversity science is to understand the factors contributing to the variability of species richness –the number of different species in a community or region - among comparable taxonomic...

    Authors: Klemen Čandek, Urška Pristovšek Čandek and Matjaž Kuntner

    Citation: BMC Biology 2020 18:105

    Content type: Research article

    Published on:

  45. Dengue virus (DENV) is estimated to infect 390 million people annually. However, few host factors that alter disease severity are known. Malnutrition, defined as both over- and undernutrition, is a growing pro...

    Authors: Christina Chuong, Tyler A. Bates, Shamima Akter, Stephen R. Werre, Tanya LeRoith and James Weger-Lucarelli

    Citation: BMC Biology 2020 18:106

    Content type: Research article

    Published on:

  46. Effective conservation management of highly mobile species depends upon detailed knowledge of movements of individuals across their range; yet, data are rarely available at appropriate spatiotemporal scales. F...

    Authors: Justin A. Welbergen, Jessica Meade, Hume E. Field, Daniel Edson, Lee McMichael, Luke P. Shoo, Jenny Praszczalek, Craig Smith and John M. Martin

    Citation: BMC Biology 2020 18:101

    Content type: Research article

    Published on:

  47. Hundreds of millions of people get a mosquito-borne disease every year and nearly one million die. Transmission of these infections is primarily tackled through the control of mosquito vectors. The accurate qu...

    Authors: Igor Filipović, Hapuarachchige Chanditha Hapuarachchi, Wei-Ping Tien, Muhammad Aliff Bin Abdul Razak, Caleb Lee, Cheong Huat Tan, Gregor J. Devine and Gordana Rašić

    Citation: BMC Biology 2020 18:104

    Content type: Research article

    Published on:

  48. The development of a safe, effective, reversible, non-hormonal contraceptive method for men has been an ongoing effort for the past few decades. However, despite significant progress on elucidating the functio...

    Authors: Matthew J. Robertson, Katarzyna Kent, Nathan Tharp, Kaori Nozawa, Laura Dean, Michelle Mathew, Sandra L. Grimm, Zhifeng Yu, Christine Légaré, Yoshitaka Fujihara, Masahito Ikawa, Robert Sullivan, Cristian Coarfa, Martin M. Matzuk and Thomas X. Garcia

    Citation: BMC Biology 2020 18:103

    Content type: Research article

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  49. Patients with pelvic malignancies often receive radiosensitising chemotherapy with radiotherapy to improve survival; however, this is at the expense of increased normal tissue toxicity, particularly in elderly...

    Authors: Chee Kin Then, Salome Paillas, Xuedan Wang, Alix Hampson and Anne E. Kiltie

    Citation: BMC Biology 2020 18:102

    Content type: Research article

    Published on:

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