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  1. Single-cell RNA sequencing (scRNA-seq) provides high-dimensional measurements of transcript counts in individual cells. However, high assay costs and artifacts associated with analyzing samples across multiple...

    Authors: Christopher S. McGinnis, David A. Siegel, Guorui Xie, George Hartoularos, Mars Stone, Chun J. Ye, Zev J. Gartner, Nadia R. Roan and Sulggi A. Lee

    Citation: BMC Biology 2021 19:10

    Content type: Research article

    Published on:

  2. The two main primate groups recorded throughout the European Miocene, hominoids and pliopithecoids, seldom co-occur. Due to both their rarity and insufficiently understood palaeoecology, it is currently unclea...

    Authors: Daniel DeMiguel, Laura Domingo, Israel M. Sánchez, Isaac Casanovas-Vilar, Josep M. Robles and David M. Alba

    Citation: BMC Biology 2021 19:6

    Content type: Research article

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  3. Regeneration is the ability to re-grow body parts or tissues after trauma, and it is widespread across metazoans. Cells involved in regeneration can arise from a pool of undifferentiated proliferative cells or...

    Authors: Laura Piovani, Anna Czarkwiani, Cinzia Ferrario, Michela Sugni and Paola Oliveri

    Citation: BMC Biology 2021 19:9

    Content type: Research article

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  4. Numerous deep-sea invertebrates, at both hydrothermal vents and methane seeps, have formed symbiotic associations with internal chemosynthetic bacteria in order to harness inorganic energy sources typically un...

    Authors: Shana K. Goffredi, Cambrie Motooka, David A. Fike, Luciana C. Gusmão, Ekin Tilic, Greg W. Rouse and Estefanía Rodríguez

    Citation: BMC Biology 2021 19:8

    Content type: Research article

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  5. Horizontal gene transfer (HGT) has been documented in many herbivorous insects, conferring the ability to digest plant material and promoting their remarkable ecological diversification. Previous reports sugge...

    Authors: Hao-Sen Li, Xue-Fei Tang, Yu-Hao Huang, Ze-Yu Xu, Mei-Lan Chen, Xue-Yong Du, Bo-Yuan Qiu, Pei-Tao Chen, Wei Zhang, Adam Ślipiński, Hermes E. Escalona, Robert M. Waterhouse, Andreas Zwick and Hong Pang

    Citation: BMC Biology 2021 19:7

    Content type: Research article

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  6. Viruses are ubiquitous biological entities, estimated to be the largest reservoirs of unexplored genetic diversity on Earth. Full functional characterization and annotation of newly discovered viruses requires...

    Authors: Congyu Lu, Zheng Zhang, Zena Cai, Zhaozhong Zhu, Ye Qiu, Aiping Wu, Taijiao Jiang, Heping Zheng and Yousong Peng

    Citation: BMC Biology 2021 19:5

    Content type: Methodology article

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  8. Identifying variants that drive tumor progression (driver variants) and distinguishing these from variants that are a byproduct of the uncontrolled cell growth in cancer (passenger variants) is a crucial step ...

    Authors: Daniele Raimondi, Antoine Passemiers, Piero Fariselli and Yves Moreau

    Citation: BMC Biology 2021 19:3

    Content type: Research article

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  9. A robust molecular phylogeny is fundamental for developing a stable classification and providing a solid framework to understand patterns of diversification, historical biogeography, and character evolution. A...

    Authors: Fei Zhao, Ya-Ping Chen, Yasaman Salmaki, Bryan T. Drew, Trevor C. Wilson, Anne-Cathrine Scheen, Ferhat Celep, Christian Bräuchler, Mika Bendiksby, Qiang Wang, Dao-Zhang Min, Hua Peng, Richard G. Olmstead, Bo Li and Chun-Lei Xiang

    Citation: BMC Biology 2021 19:2

    Content type: Research article

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  10. Dinoflagellates are aquatic protists particularly widespread in the oceans worldwide. Some are responsible for toxic blooms while others live in symbiotic relationships, either as mutualistic symbionts in cora...

    Authors: Sarah Farhat, Phuong Le, Ehsan Kayal, Benjamin Noel, Estelle Bigeard, Erwan Corre, Florian Maumus, Isabelle Florent, Adriana Alberti, Jean-Marc Aury, Tristan Barbeyron, Ruibo Cai, Corinne Da Silva, Benjamin Istace, Karine Labadie, Dominique Marie…

    Citation: BMC Biology 2021 19:1

    Content type: Research article

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  11. A major task of the endosomal sorting complex required for transport (ESCRT) machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of maturing endosomes (MEs), which is esse...

    Authors: Miriam Baeumers, Kristina Ruhnau, Thomas Breuer, Hendrik Pannen, Bastian Goerlich, Anna Kniebel, Sebastian Haensch, Stefanie Weidtkamp-Peters, Lutz Schmitt and Thomas Klein

    Citation: BMC Biology 2020 18:200

    Content type: Research article

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  12. Repetitive DNA sequences, including transposable elements (TEs) and tandemly repeated satellite DNA (satDNAs), collectively called the “repeatome”, are found in high proportion in organisms across the Tree of ...

    Authors: Octavio M. Palacios-Gimenez, Julia Koelman, Marc Palmada-Flores, Tessa M. Bradford, Karl K. Jones, Steven J. B. Cooper, Takeshi Kawakami and Alexander Suh

    Citation: BMC Biology 2020 18:199

    Content type: Research article

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lee Shaashua, Anabel Eckerling, Boaz Israeli, Gali Yanovich, Ella Rosenne, Suzana Fichman-Horn, Ido Ben Zvi, Liat Sorski, Rita Haldar, Ronit Satchi-Fainaro, Tamar Geiger, Erica K. Sloan and Shamgar Ben-Eliyahu

    Citation: BMC Biology 2020 18:198

    Content type: Publisher Correction

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    The original article was published in BMC Biology 2020 18:163

  14. The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), T...

    Authors: Francesco De Logu, Gabriela Trevisan, Ilaria Maddalena Marone, Elisabetta Coppi, Diéssica Padilha Dalenogare, Mustafa Titiz, Matilde Marini, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Simone Li Puma, Serena Materazzi, Gaetano De Siena, Pierangelo Geppetti and Romina Nassini

    Citation: BMC Biology 2020 18:197

    Content type: Research article

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  15. Ammonium (NH4+), a key nitrogen form, becomes toxic when it accumulates to high levels. Ammonium transporters (AMTs) are the key transporters responsible for NH4+ uptake. AMT activity is under allosteric feedback...

    Authors: Hui-Yu Chen, Yen-Ning Chen, Hung-Yu Wang, Zong-Ta Liu, Wolf B. Frommer and Cheng-Hsun Ho

    Citation: BMC Biology 2020 18:196

    Content type: Research article

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  16. Elasticity prevents fatigue of tissues that are extensively and repeatedly deformed. Resilin is a resilient and elastic extracellular protein matrix in joints and hinges of insects. For its mechanical properti...

    Authors: Steven Lerch, Renata Zuber, Nicole Gehring, Yiwen Wang, Barbara Eckel, Klaus-Dieter Klass, Fritz-Olaf Lehmann and Bernard Moussian

    Citation: BMC Biology 2020 18:195

    Content type: Research article

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  17. It is widely assumed that all mutant microorganisms present in a culture are able to grow and form colonies, provided that they express the features required for selection. Unlike wild-type Escherichia coli, PHO-...

    Authors: Henrique Iglesias Neves, Gabriella Trombini Machado, Taíssa Cristina dos Santos Ramos, Hyun Mo Yang, Ezra Yagil and Beny Spira

    Citation: BMC Biology 2020 18:194

    Content type: Research article

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  18. Adenine base editors (ABE) enable single nucleotide modifications without the need for double-stranded DNA breaks (DSBs) induced by conventional CRIPSR/Cas9-based approaches. However, most approaches that empl...

    Authors: Nicholas Brookhouser, Toan Nguyen, Stefan J. Tekel, Kylie Standage-Beier, Xiao Wang and David A. Brafman

    Citation: BMC Biology 2020 18:193

    Content type: Research article

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  19. Subclinical atherosclerosis may result in fatal cardiovascular (CV) events, but the underlying mechanisms and molecular players leading to disease are not entirely understood. Thus, novel approaches capable of...

    Authors: Marta Agudiez, Paula J. Martinez, Marta Martin-Lorenzo, Angeles Heredero, Aranzazu Santiago-Hernandez, Dolores Molero, Juan Manuel Garcia-Segura, Gonzalo Aldamiz-Echevarria and Gloria Alvarez-Llamas

    Citation: BMC Biology 2020 18:192

    Content type: Research article

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  20. The vast majority of all life that ever existed on earth is now extinct and several aspects of their evolutionary history can only be assessed by using morphological data from the fossil record. Sphenodontian ...

    Authors: Tiago R. Simões, Michael W. Caldwell and Stephanie E. Pierce

    Citation: BMC Biology 2020 18:191

    Content type: Research article

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  22. The adenosine-to-inosine (A-to-I) editing in anticodons of tRNAs is critical for wobble base-pairing during translation. This modification is produced via deamination on A34 and catalyzed by the adenosine deam...

    Authors: Xiwen Liu, Ruoyu Chen, Yujie Sun, Ran Chen, Jie Zhou, Qingnan Tian, Xuan Tao, Zhang Zhang, Guan-zheng Luo and Wei Xie

    Citation: BMC Biology 2020 18:189

    Content type: Research article

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  23. The speciation and fast global domestication of bread wheat have made a great impact on three subgenomes of bread wheat. DNA base composition is an essential genome feature, which follows the individual-strand...

    Authors: Yan Zhao, Luhao Dong, Conghui Jiang, Xueqiang Wang, Jianyin Xie, Muhammad Abdul Rehman Rashid, Yanhe Liu, Mengyao Li, Zhimu Bu, Hongwei Wang, Xin Ma, Silong Sun, Xiaoqian Wang, Cunyao Bo, Tingting Zhou and Lingrang Kong

    Citation: BMC Biology 2020 18:188

    Content type: Research article

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  24. The family Trypanosomatidae encompasses parasitic flagellates, some of which cause serious vector-transmitted diseases of humans and domestic animals. However, insect-restricted parasites represent the ancestr...

    Authors: Alexei Y. Kostygov, Alexander O. Frolov, Marina N. Malysheva, Anna I. Ganyukova, Lyudmila V. Chistyakova, Daria Tashyreva, Martina Tesařová, Viktoria V. Spodareva, Jana Režnarová, Diego H. Macedo, Anzhelika Butenko, Claudia M. d’Avila-Levy, Julius Lukeš and Vyacheslav Yurchenko

    Citation: BMC Biology 2020 18:187

    Content type: Research article

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  26. The study of convergently acquired adaptations allows fundamental insight into life’s evolutionary history. Within lepidosaur reptiles—i.e. lizards, tuatara, and snakes—a fully fossorial (‘burrowing’) lifestyl...

    Authors: Roy Ebel, Johannes Müller, Till Ramm, Christy Hipsley and Eli Amson

    Citation: BMC Biology 2020 18:185

    Content type: Research article

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  27. Ciliates are an ancient and diverse eukaryotic group found in various environments. A unique feature of ciliates is their nuclear dimorphism, by which two types of nuclei, the diploid germline micronucleus (MI...

    Authors: Yu-Hsuan Cheng, Chien-Fu Jeff Liu, Yen-Hsin Yu, Yu-Ting Jhou, Masahiro Fujishima, Isheng Jason Tsai and Jun-Yi Leu

    Citation: BMC Biology 2020 18:180

    Content type: Research article

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  28. Survival to cold stress in insects living in temperate environments requires the deployment of strategies that lead to physiological changes involved in freeze tolerance or freeze avoidance. These strategies m...

    Authors: Bin Zhang, Lilin Zhao, Jing Ning, Jacob D. Wickham, Haokai Tian, Xiaoming Zhang, Meiling Yang, Xiangming Wang and Jianghua Sun

    Citation: BMC Biology 2020 18:184

    Content type: Research article

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  30. Visually guided behaviors such as optomotor and optokinetic responses, phototaxis, and prey capture are crucial for survival in zebrafish and become apparent after just a few days of development. Color vision,...

    Authors: Chiara Fornetto, Natascia Tiso, Francesco Saverio Pavone and Francesco Vanzi

    Citation: BMC Biology 2020 18:172

    Content type: Research article

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  31. Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes...

    Authors: Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu…

    Citation: BMC Biology 2020 18:182

    Content type: Research article

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  32. Nematodes have evolved to survive in diverse ecological niches and can be a serious burden on agricultural economy, veterinary medicine, and public health. Antioxidant enzymes in parasitic nematodes play a cri...

    Authors: Lian Xu, Jian Yang, Meng Xu, Dai Shan, Zhongdao Wu and Dongjuan Yuan

    Citation: BMC Biology 2020 18:181

    Content type: Research article

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  33. A recent paper in BMC Biology entitled “A tissue level atlas of the healthy human virome” by Kumata et al. describes a meta-transcriptomic analysis of RNA-sequencing datasets from the Genotype-Tissue Expression (...

    Authors: Signe Altmäe, Nerea M. Molina and Alberto Sola-Leyva

    Citation: BMC Biology 2020 18:179

    Content type: Correspondence

    Published on:

    The original article was published in BMC Biology 2020 18:55

  34. The complex composition of different cell types within a tissue can be estimated by deconvolution of bulk gene expression profiles or with various single-cell sequencing approaches. Alternatively, DNA methylat...

    Authors: Marco Schmidt, Tiago Maié, Edgar Dahl, Ivan G. Costa and Wolfgang Wagner

    Citation: BMC Biology 2020 18:178

    Content type: Methodology article

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  35. Many biological processes, such as cancer metastasis, organismal development, and acquisition of resistance to cytotoxic therapy, rely on the emergence of rare sub-clones from a larger population. Understandin...

    Authors: David Feldman, FuNien Tsai, Anthony J. Garrity, Ryan O’Rourke, Lisa Brenan, Patricia Ho, Elizabeth Gonzalez, Silvana Konermann, Cory M. Johannessen, Rameen Beroukhim, Pratiti Bandopadhayay and Paul C. Blainey

    Citation: BMC Biology 2020 18:177

    Content type: Research article

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  38. In recent years, large-scale genetic screens using the CRISPR/Cas9 system have emerged as scalable approaches able to interrogate gene function with unprecedented efficiency and specificity in various biologic...

    Authors: Luisa Henkel, Benedikt Rauscher, Barbara Schmitt, Jan Winter and Michael Boutros

    Citation: BMC Biology 2020 18:174

    Content type: Methodology article

    Published on:

  39. It has become increasingly accepted that establishing and maintaining a complex and diverse gut microbiota is fundamental to human health. There are growing efforts to identify means of modulating and influenc...

    Authors: Lorraine A. Draper, Feargal J. Ryan, Marion Dalmasso, Pat G. Casey, Angela McCann, Vimalkumar Velayudhan, R. Paul Ross and Colin Hill

    Citation: BMC Biology 2020 18:173

    Content type: Research article

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  40. Wheat is a powerful genetic model for studying polyploid evolution and crop domestication. Hexaploid bread wheat was formed by two rounds of interspecific hybridization and polyploidization, processes which ar...

    Authors: Jingya Yuan, Wu Jiao, Yanfeng Liu, Wenxue Ye, Xiue Wang, Bao Liu, Qingxin Song and Z. Jeffrey Chen

    Citation: BMC Biology 2020 18:171

    Content type: Research article

    Published on:

  41. Despite the widespread occurrence of axon and synaptic loss in the injured and diseased nervous system, the cellular and molecular mechanisms of these key degenerative processes remain incompletely understood....

    Authors: Alison Jane Canty, Johanna Sara Jackson, Lieven Huang, Antonio Trabalza, Cher Bass, Graham Little, Maria Tortora, Shabana Khan and Vincenzo De Paola

    Citation: BMC Biology 2020 18:170

    Content type: Research article

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  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dorith Rotenberg, Aaron A. Baumann, Sulley Ben-Mahmoud, Olivier Christiaens, Wannes Dermauw, Panagiotis Ioannidis, Chris G. C. Jacobs, Iris M. Vargas Jentzsch, Jonathan E. Oliver, Monica F. Poelchau, Swapna Priya Rajarapu, Derek J. Schneweis, Simon Snoeck, Clauvis N. T. Taning, Dong Wei, Shirani M. K. Widana Gamage…

    Citation: BMC Biology 2020 18:169

    Content type: Author Correction

    Published on:

    The original article was published in BMC Biology 2020 18:142

  43. A wide variety of photosynthetic and non-photosynthetic species sense and respond to light, having developed protective mechanisms to adapt to damaging effects on DNA and proteins. While the biology of UV ligh...

    Authors: Mikael Molin, Katarina Logg, Kristofer Bodvard, Ken Peeters, Annabelle Forsmark, Friederike Roger, Anna Jörhov, Neha Mishra, Jean-Marc Billod, Sabiha Amir, Mikael Andersson, Leif A. Eriksson, Jonas Warringer, Mikael Käll and Anders Blomberg

    Citation: BMC Biology 2020 18:168

    Content type: Research article

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  44. Structural variants comprise diverse genomic arrangements including deletions, insertions, inversions, and translocations, which can generally be detected in humans through sequence comparison to the reference...

    Authors: Young-gun Lee, Jin-young Lee, Junhyong Kim and Young-Joon Kim

    Citation: BMC Biology 2020 18:167

    Content type: Research article

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  45. Sensory systems acquire both external and internal information to guide behavior. Adjustments based on external input are much better documented and understood than internal-based sensory adaptations. When ext...

    Authors: Arjan Boonman, Itai Rieger, Eran Amichai, Stefan Greif, Ofri Eitan, Aya Goldshtein and Yossi Yovel

    Citation: BMC Biology 2020 18:166

    Content type: Research article

    Published on:

  46. Chromosome-level assemblies are indispensable for accurate gene prediction, synteny assessment, and understanding higher-order genome architecture. Reference and draft genomes of key helminth species have been...

    Authors: Peter D. Olson, Alan Tracey, Andrew Baillie, Katherine James, Stephen R. Doyle, Sarah K. Buddenborg, Faye H. Rodgers, Nancy Holroyd and Matt Berriman

    Citation: BMC Biology 2020 18:165

    Content type: Research article

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  47. Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effe...

    Authors: Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco Carvajal, Fernanda G. Guerrero, Fabian Segovia-Miranda, David M. Valenzuela, Ursula Wyneken, Alejandro Rojas-Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela-Nallar and Alfonso González

    Citation: BMC Biology 2020 18:164

    Content type: Research article

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  48. Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes. In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE transc...

    Authors: Ulfar Bergthorsson, Caroline J. Sheeba, Anke Konrad, Tony Belicard, Toni Beltran, Vaishali Katju and Peter Sarkies

    Citation: BMC Biology 2020 18:162

    Content type: Research article

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  49. The Wolbachia incompatible insect technique (IIT) shows promise as a method for eliminating populations of invasive mosquitoes such as Aedes aegypti (Linnaeus) (Diptera: Culicidae) and reducing the incidence of v...

    Authors: D. E. Pagendam, B. J. Trewin, N. Snoad, S. A. Ritchie, A. A. Hoffmann, K. M. Staunton, C. Paton and N. Beebe

    Citation: BMC Biology 2020 18:161

    Content type: Research article

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  50. Circadian rhythms across mammalian tissues are coordinated by a master clock in the suprachiasmatic nucleus (SCN) that is principally entrained by light-dark cycles. Prior investigations have shown, however, t...

    Authors: Xiaobin Xie, Ayaka Kukino, Haley E. Calcagno, Alec M. Berman, Joseph P. Garner and Matthew P. Butler

    Citation: BMC Biology 2020 18:160

    Content type: Research article

    Published on:

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