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  1. Content type: Research article

    The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease...

    Authors: Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel and Sonia M. Brichard

    Citation: BMC Biology 2018 16:33

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  2. Content type: Research article

    Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that ...

    Authors: Asghar M. Razavi, George Khelashvili and Harel Weinstein

    Citation: BMC Biology 2018 16:31

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  3. Content type: Research article

    Eukaryotes evolved from the symbiotic association of at least two prokaryotic partners, and a good deal is known about the timings, mechanisms, and dynamics of these evolutionary steps. Recently, it was shown ...

    Authors: Raphaël Méheust, Debashish Bhattacharya, Jananan S. Pathmanathan, James O. McInerney, Philippe Lopez and Eric Bapteste

    Citation: BMC Biology 2018 16:30

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  4. Content type: Research article

    The Golgi apparatus is a central meeting point for the endocytic and exocytic systems in eukaryotic cells, and the organelle’s dysfunction results in human disease. Its characteristic morphology of multiple di...

    Authors: Lael D. Barlow, Eva Nývltová, Maria Aguilar, Jan Tachezy and Joel B. Dacks

    Citation: BMC Biology 2018 16:27

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  5. Content type: Research article

    Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects...

    Authors: Virginia Tajadura-Ortega, Ritu Garg, Richard Allen, Claudia Owczarek, Michael D. Bright, Samuel Kean, Aisyah Mohd-Noor, Anita Grigoriadis, Timothy C. Elston, Klaus M. Hahn and Anne J. Ridley

    Citation: BMC Biology 2018 16:29

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  6. Content type: Software

    Multiple RNA samples are frequently processed together and often mixed before multiplex sequencing in the same sequencing run. While different samples can be separated post sequencing using sample barcodes, th...

    Authors: Paul Simion, Khalid Belkhir, Clémentine François, Julien Veyssier, Jochen C. Rink, Michaël Manuel, Hervé Philippe and Maximilian J. Telford

    Citation: BMC Biology 2018 16:28

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  7. Content type: Research article

    Associations between traits are prevalent in nature, occurring across a diverse range of taxa and traits. Individual traits may co-evolve with one other, and these correlations can be driven by factors intrins...

    Authors: Dana A. Opulente, Emily J. Rollinson, Cleome Bernick-Roehr, Amanda Beth Hulfachor, Antonis Rokas, Cletus P. Kurtzman and Chris Todd Hittinger

    Citation: BMC Biology 2018 16:26

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  8. Content type: Research article

    G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (A1R or A2AR) can form A1R-A2AR heteromers (...

    Authors: Gemma Navarro, Arnau Cordomí, Marc Brugarolas, Estefanía Moreno, David Aguinaga, Laura Pérez-Benito, Sergi Ferre, Antoni Cortés, Vicent Casadó, Josefa Mallol, Enric I. Canela, Carme Lluís, Leonardo Pardo, Peter J. McCormick and Rafael Franco

    Citation: BMC Biology 2018 16:24

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  9. Content type: Methodology article

    The ability to efficiently visualize and manipulate chromosomes is fundamental to understanding the genome architecture of organisms. Conventional chromosome preparation protocols developed for mammalian cells...

    Authors: Longhua Guo, Alice Accorsi, Shuonan He, Carlos Guerrero-Hernández, Shamilene Sivagnanam, Sean McKinney, Matthew Gibson and Alejandro Sánchez Alvarado

    Citation: BMC Biology 2018 16:25

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  10. Content type: Review

    The need for high-throughput, precise, and meaningful methods for measuring behavior has been amplified by our recent successes in measuring and manipulating neural circuitry. The largest challenges associated...

    Authors: Gordon J. Berman

    Citation: BMC Biology 2018 16:23

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  11. Content type: Review

    Paraphrasing Dobzhansky’s famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging ...

    Authors: Mel Greaves

    Citation: BMC Biology 2018 16:22

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  12. Content type: Research article

    In plants, the shoot apical meristem (SAM) has two main functions, involving the production of all aerial organs on the one hand and self-maintenance on the other, allowing the production of organs during the ...

    Authors: Thomas Stanislas, Matthieu Pierre Platre, Mengying Liu, Léa E. S. Rambaud-Lavigne, Yvon Jaillais and Olivier Hamant

    Citation: BMC Biology 2018 16:20

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  13. Content type: Research article

    Mammalian small intestinal tight junctions (TJ) link epithelial cells to one another and function as a permselective barrier, strictly modulating the passage of ions and macromolecules through the pore and lea...

    Authors: Sarah C. Pearce, Arwa Al-Jawadi, Kunihiro Kishida, Shiyan Yu, Madeleine Hu, Luke F. Fritzky, Karen L. Edelblum, Nan Gao and Ronaldo P. Ferraris

    Citation: BMC Biology 2018 16:19

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  14. Content type: Research article

    Environmental stressors induce changes in endocrine state, leading to energy re-allocation from reproduction to survival. Female Drosophila melanogaster respond to thermal and nutrient stressors by arresting egg ...

    Authors: Matthew R. Meiselman, Timothy G. Kingan and Michael E. Adams

    Citation: BMC Biology 2018 16:18

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  15. Content type: Question and Answer

    Caenorhabditis elegans neurons have recently been found to throw out cellular debris for remote degradation and/or storage, adding an “extracellular garbage elimination” option to known intracellular protein and ...

    Authors: Meghan Lee Arnold, Ilija Melentijevic, Anna Joelle Smart and Monica Driscoll

    Citation: BMC Biology 2018 16:17

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  16. Content type: Research article

    Sex determination relies on a hierarchically structured network of genes, and is one of the most plastic processes in evolution. The evolution of sex-determining genes within a network, by neo- or sub-function...

    Authors: Manfred Schartl, Susanne Schories, Yuko Wakamatsu, Yusuke Nagao, Hisashi Hashimoto, Chloé Bertin, Brigitte Mourot, Cornelia Schmidt, Dagmar Wilhelm, Lazaro Centanin, Yann Guiguen and Amaury Herpin

    Citation: BMC Biology 2018 16:16

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  17. Content type: Research article

    Polyploidization is one of the major evolutionary processes that shape eukaryotic genomes, being particularly common in plants. Polyploids can arise through direct genome doubling within a species (autopolyplo...

    Authors: Irene Julca, Marina Marcet-Houben, Pablo Vargas and Toni Gabaldón

    Citation: BMC Biology 2018 16:15

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  18. Content type: Research article

    The bone morphogenetic protein (BMP) signaling gradient is central for dorsoventral patterning in amphibian embryos. This gradient is established through the interaction of several BMPs and BMP antagonists and...

    Authors: Avi Leibovich, Hadas Kot-Leibovich, Danny Ben-Zvi and Abraham Fainsod

    Citation: BMC Biology 2018 16:13

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  19. Content type: Research article

    The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only b...

    Authors: Fabian Moine, Julien Brechbühl, Monique Nenniger Tosato, Manon Beaumann and Marie-Christine Broillet

    Citation: BMC Biology 2018 16:12

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  20. Content type: Review

    Efficient movement of proteins across membranes is required for cell health. The translocation process is particularly challenging when the channel in the membrane through which proteins must pass is narrow—su...

    Authors: Elizabeth A. Craig

    Citation: BMC Biology 2018 16:11

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  21. Content type: Research article

    Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential ...

    Authors: Edward R. Ballister, Jessica Rodgers, Franck Martial and Robert J. Lucas

    Citation: BMC Biology 2018 16:10

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  22. Content type: Methodology article

    Caenorhabditis elegans nematodes are powerful model organisms, yet quantification of visible phenotypes is still often labor-intensive, biased, and error-prone. We developed WorMachine, a three-step MATLAB-based ...

    Authors: Adam Hakim, Yael Mor, Itai Antoine Toker, Amir Levine, Moran Neuhof, Yishai Markovitz and Oded Rechavi

    Citation: BMC Biology 2018 16:8

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