Figure 1From: Altered metabolism in cancerCell-autonomous control of growth and metabolism are acquired upon cell transformation by mutation. Cells in a normal tissue (left-hand diagram) are constrained in their growth by their environment (depicted as green lines). During the development of a tumor (right-hand diagram), cells acquire mutations that allow growth outside the context of normal tissue development. As a result, metabolic pathways are reorganized and metabolism is altered to allow for cell-autonomous growth.Back to article page