Fig. 5
From: Quantitative framework for ordered degradation of APC/C substrates
Two-substrate system in which C has higher affinity than S for APC/CCdc20. The parameter space shown is k c -k d of S; at any parameter combination, k d,C  = 1/10*k d,S . a Relative difference in degradation onset (T95) comparing S to C. b Difference in degradation rates of C and S, shown as the ratio of Td of C over Td of S. c Middle panel: change of T95 of S in two-substrate system compared to one-substrate system. Left and right panels: degradation profiles of a one-substrate system and two-substrate system showing the dynamics of different molecular species at the parameter values indicated on the middle panel by dashed lines. d In the two-substrate system, the maximum fraction of C-bound APC/CCdc20. APC/C anaphase-promoting complex/cyclosome