Fig. 7.

Kupffer cells, monocytes and macrophages interact with sinusoidal epithelium, hepatocytes and immune cells. a Normal mouse liver. Sinusoids (asterisks) are bordered by F4/80+ Kupffer cells (arrows) and F4/80 negative endothelial cells (arrowheads), in close proximity to hepatocytes, which are often binucleated (broken arrow). b, c Granuloma formation. Macrophages in granulomas induced by the mycobacterial vaccine Bacille Calmette Guérin (BCG) express F/80 antigen (bold arrows) on a background of activated Kupffer cells (slender arrows) and activated monocytes (b); BCG-induced recruitment of activated monocytes in sinusoids (triangles) and M1 activated macrophages in granulomas (arrows), which express lysozyme strongly and uniformly, detected by in situ hybridisation. See [115] for further details