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Table 1 Optimal CS ratios to elucidate YAC128 MSN phenotypes in co-culture

From: Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

YAC128 MSN Phenotype

Optimal CS ratio

Spine loss

1:3

Impaired neuronal survival

1:3

Decreased dendritic length/complexity

1:1

Reduced mEPSC frequency

1:1

Reduced membrane capacitance

1:1