Table 2 Cancer risk genotypes identified in genome-wide association studies of 173 hpEurope isolates

HP1055 [981621–982,565] (−)

1.4.10⁻⁹

A

798

C

S, associated with G to A substitution at position 797: non-synonymous with T in safe, A in risk

Outer membrane protein

HP0797 [506543–507,325] (+)

2.24.10⁻⁸

C + T

325 and 334

T + G

NS: L/S in safe, F/A in risk

Neuraminyllactose-binding hemagglutinin (HpaA) [29]

HP1243,babA1 [1314192–1,316,405] (−)

3.99.10⁻⁸

Presence

All genes

Absence

BabA (outer membrane protein) [16]

HP0747 [317158–317,757] (+)

1.69.10^− 7

GGAA

934 to 937

AAAA/GGAG

NS: KA in safe, GT in risk

tRNA (guanine-N(7)-)-methyltransferase

HP0709 [598549–599,451] (−)

2.13.10^− 7

A

145

G

NS: D in safe, N in risk

Adenosyl-chloride synthase

A

159

G

S

HP0532,cag12 [817677–818,519] (+)

3.62.10^− 7

Presence

All genes

Absence

CagT protein (Censini, 1996)

HP0468 [925539–927,026] (+)

4.59.10^− 7

CGCC

705 to 708

CACG/TGCG

NS: T in safe, A in risk

Unknown

A

729

G

S

HP0531,cag11 [816985–817,641] (+)

5.4.10⁻⁷

Presence

All genes

Absence

CagU protein (Censini, 1996)

HP0541,cag20 [825334–826,446] (−)

6.6.10⁻⁷

Presence

All genes

Absence

CagH protein (Censini, 1996)