Fig. 6

The possible relationship between EICD generation and the prognosis of patients with breast cancer. a The Kaplan-Meier survival analysis of four patients with breast cancer grouped by ER status and SPPL2B expression (hi, high; lo, low) is shown. b The Kaplan-Meier survival analysis of patients that were ER-negative grouped by expression levels of epithin/PRSS14 and SPPL2B is shown. The p values were calculated using log-rank statistics. *p < 0.05; **p < 0.01; ***p < 0.001. c A hypothetical model for EICD generation and dual functions of epithin/PRSS14 in metastasis are illustrated