Fig. 1
From: System-wide molecular dynamics of endothelial dysfunction in Gram-negative sepsis
Validation of the SILAM model for the study of protein dynamics in severe inflammatory response. a Comparison of the number of SILAM-labeled proteins detected in glycocalyx (GC), endothelial cells (EC) and smooth muscle cells (SMC) proteomes after endotoxemia (LPS) versus Control. b Number of tryptic digested SILAM-labeled peptides detected in the three analyzed vascular beds (GC, EC, and SMC). c–h Frequency distribution curves for the incorporation of Lys(6) in individual proteins calculated for every vascular bed (GC, EC, and SMC) after LPS versus Control. i Adjusted curve comparison for the SILAM-labeled proteins in different vascular beds from Control and LPS-treated mice