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Table 1 No evidence in favor of a post-retrieval amnestic effect

From: Lack of drug-induced post-retrieval amnesia for auditory fear memories in rats

Experiment

Figure

Drug condition

n

Control condition

n

Reactivation CS (two-sided t test)

Retention test

Retention test (one-sided t test, drug < control)

Retention test (RM ANOVA, Trial by group effect)

Retention test (Bayesian one-sided t test, drug < control)

Retention test (Bayesian evidence against drug < control)

Retention test (Bayesian one-sided meta-analysis)

Experiment 1

1b

Prop

8

Sal

8

t(14) = 0.29, p = .78

Test 1 (4 CSs)

t(14) = 0.12, p = .55

F(3,42) = 0.96, p = .42

BF01 = 2.52

Anecdotal

BF01 = 9.93, suggesting substantial evidence for the absence of an amnestic effect

Experiment 1

1b

Prop

8

Prop NoReact

8

NA

Test 1 (4 CSs)

t(14) = 0.01, p = .50

F(3,42) = 2.02, p = .13

BF01 = 2.35

Anecdotal

Experiment 2

1d

Prop

8

Sal

8

t(14) = − 0.09, p = .93

Test 1 (4 CSs)

t(14) = 0.01, p = .50

F(3,42) = 0.56, p = .64

BF01 = 2.35

Anecdotal

Experiment 3

1f

Prop

8

Sal

6

t(12) = − 0.13, p = .90

Test 1 (4 CSs)

t(12) = 0.84, p = .79

F(3,36) = 0.69, p = .57

BF01 = 3.45

Substantial

Experiment 4

1h

Prop

5

Sal

7

t(10) = −.0.37, p = .72

Test 1 (4 CSs)

t(4.52) = − 0.77, p = .24

F(3,30) = 0.24, p = .87

BF01 = 1.09

Anecdotal

Experiment 5

2b

Rap 20

8

Veh

8

t(14) = 1.34, p = .20

Test 1 (4 CSs)

t(14) = 1.43, p = .91

F(3,42) = 0.59, p = 0.63

BF01 = 4.59

Substantial

Experiment 6

2d

Rap 40

8

Veh

8

t(14) = −1.38, p = .19

Test 1 (4 CSs)

t(14) = 0.51, p = .69

F(3,42) = 1.83, p = .16

BF01 = 3.13

Substantial

Experiment 7

3b

Ani

10

Veh

12

t(20) = − 0.97, p = .34

Test 2 (3 CSs)

t(10.08) = − 0.49, p = .32

F(2,40) = 0.33, p = .72

BF01 = 1.75

Anecdotal

Experiment 7

3b

Cyclo

14

Veh

12

t(24) = − 0.91, p = .37

Test 2 (3 CSs)

t(24) = 1.04, p = .84

F(2,80) = 1.39, p = .26

BF01 = 4.83

Substantial

  1. Statistical evaluation of post-retrieval amnesia with systemic administration of propranolol, rapamycin, anisomycin, or cycloheximide provides no evidence in favor of an amnestic effect. Note that BF01 quantifies the obtained evidence in favor of the null hypothesis (i.e., absence of an amnestic effect) relative to the alternative hypothesis (i.e., presence of an amnestic effect). For the Bayesian meta-analysis, the comparison of Prop versus Prop NoReact in experiment 1 was not included as this was a comparison with an additional control condition. Ani anisomycin (150 mg/kg), Cyclo cycloheximide (1.5 mg/kg), Prop propranolol (10 mg/kg), Rap 20 rapamycin (20 mg/kg), Rap 40 rapamycin (40 mg/kg), Sal saline, Veh vehicle