Fig. 9

Proposed model for the action of miR827 and GPLα. MiR827 controls the expression of PHT1 and Pi levels, by modulating the target NLA that negatively controls PHT1 protein level and in parallel, controlling GPLα expression, which also negatively controls PHT1 gene expression. Altered PHT1 levels affect tissue Pi levels. MiR827 controls the progression of senescence by modulating the target NLA that negatively controls protein levels of ORE1, which acts as a positive regulator of senescence, and in parallel modulating the expression of GPLα, which negatively controls senescence. MiR827 induction leads to increased PHT1 levels in parallel to its inducing effect on senescence via its effects on NLA and GPLα. Negative effect is indicated by red inhibitory signs and positive effect by blue arrows. Double-headed dashed black arrow indicates balanced changes