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Fig. 4 | BMC Biology

Fig. 4

From: Acute cannabinoids impair association learning via selectively enhancing synaptic transmission in striatonigral neurons

Fig. 4

Enhancing D1 MSN activities induced impairment of NRL similar to that induced by HU210 administration. A The injection site of rAAV-DIO-hM3Dq-mCherry virus. B The experimental procedure. C Electrophysiological recordings of representative D1 MSNs infected with hM3Dq virus recorded before and after 10 μmol/L CNO perfusion. D Escape latency curves of two groups (Control-mCherry vs. DREADD-hM3Dq). E–G Compared with the Control-mCherry group, the DREADD-hM3Dq group exhibited significantly increased tELS (E), failures (F), and TMCS (G) during NRL. Control-mCherry, mice were injected with rAAV-hSyn-DIO-mCherry virus; DREADD-hM3Dq, mice were injected with rAAV-hSyn-DIO-hM3Dq-mCherry virus. Control-mCherry: n = 7; DREADD-hM3Dq: n = 7. Data shown as mean ± SEM. ANOVA (D), unpaired t-test (E), and Mann-Whitney test (F, G): ***p < 0.001

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BMC Biology

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