Fig. 7From: Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibitionIllustration of Cdk5-JIP1-Notch1 axis in regulation of axonal outgrowth. A Cdk5/p35-mediated JIP1 phosphorylation boosts phosphorylation of Itch by Cdk5, which facilitates proteasome degradation of Notch1, resulting in enhanced axonal outgrowth. B Loss of JIP1 or p35 leads to an accumulation of Notch1, which result in inhibition of axonal outgrowthBack to article page