Fig. 2

Heatmap of the IC₅₀ values of gossypol derivatives against infection of ZIKV with different strains. Inhibitory activity of “hit” gossypol derivatives against ZIKV infection is expressed as IC₅₀. Gossypol was used as a control. Human strains are highlighted in yellow, mosquito strain is in green, and rhesus strain is in red. The SI values were calculated based on the average IC₅₀ values (human strains) and the respective CC₅₀ values (i.e., CC₅₀/IC₅₀). The data are presented as the mean of duplicate wells in each experiment. The experiments were repeated twice with similar results. Magenta indicates a low IC₅₀ or CC₅₀ value whereas dark blue indicates a high IC₅₀ or CC₅₀ value