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Fig. 10 | BMC Biology

Fig. 10

From: The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures

Fig. 10

In vitro activity of YAT2150 and DONE3TCl on Plasmodium gametocytes and liver stages. A Effect of the drugs on P. falciparum early and late gametocytes. Bars represent mean ± SD of two independent experiments. B Dose-dependent response of YAT2150, DONE3TCl, and atovaquone (ATQ) against the hepatic stage of P. berghei infection. Total parasite load (infection scale, bars) and cell viability (cell confluency scale, red dots) are shown. Results were normalized to DMSO and are represented as mean ± SD of three independent experiments. Reference drug is atovaquone (IC50 = 1.63 ± 0.27 nM)

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BMC Biology

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