Fig. 5
From: A novel nuclear receptor subfamily enlightens the origin of heterodimerization
Full-length NR7 can heterodimerize with RXR on DNA. SEC-nMS analyses of full-length NR7 and RXR with A DR0, B DR4, C IR3, and D Ctrl(−) response elements (Additional file 1: Table S2). For each analysis, left panels correspond to the respective chromatograms where the main chromatographic peaks are colored in A blue, B green, C red, and D beige. Right panels correspond to the extracted mass spectra of the main chromatographic peaks. The different charge states of identified NR7 homodimers, NR7-RXR heterodimer, and RXR homodimers all bound to DNA are given in blue, purple, and green respectively while the charge states of NR7 and RXR alone are given in grey and black respectively. The masses corresponding to these identified species are summarized in Additional file 1: Table S4