Fig. 6

NR7-specific communication pathways. A Communication pathways in class I and class II nuclear receptors are depicted by arrows between class-specific residues. B Communication pathways in NR7. Some pathways of class I NRs are conserved in NR7, such as the aromatic residues at the junction between helices H4 and H5 and the Glu (H8) to Arg (in the loop H9-H10) interaction. Additionally, specific interactions are seen with the universally conserved arginine residue in the loop between H10 and H11 (Arg359). The numbering of residues shown in green and red correspond to the B. lanceolatum NR7 sequence, whereas the numbering of residues shown in black refer to the generic numbering defined previously [1]. C Mapping of the NR7 residues and interactions defining the communication pathways on the NR7 crystal structure shown as ribbons. The H10’-H11’ and H12 region is depicted in cyan, helices H4–H5 in orange, helix H8 in red, and helix H9 in violet