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Fig. 3 | BMC Biology

Fig. 3

From: Circular RNAs arising from synaptic host genes during human neuronal differentiation are modulated by SFPQ RNA-binding protein

Fig. 3

Genetic variant frequency in circRNA-forming exons. a Schematic depicting how exons were subdivided for comparative analysis. BSJ, back-spliced junctions. b Frequency of GnomAD exon variants for circRNAs detected in this study, normalised for exon size (Kb). c Proportion of GnomAD exon variants annotated as having either low, medium, or high impact. d Frequency of GnomAD splice-region exon variants/Kb. e Frequency of rare de novo ASD variants/Kb. f Frequency of rare de novo ASD variants/Kb in exons of circRNAs arising from ASD-associated SFARI host genes. Two-sample Z-test/Wilcox test, ****p < 0.0001, ***p < 0.001, *p < 0.05. DNVs, de novo variants

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BMC Biology

ISSN: 1741-7007

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