Fig. 2

The most prevalent bee venom proteins. Components selected from our own data (A.) A. mellifera, H. scabiosae and X. violacea profiles, and (B.) published bee and aculeate venom components. In (A.) only venom protein transcripts validated by the proteome data are listed. Transcript expression is shown as thickness of the Circos plot lines and based on the percentage of scaled transcript per million (TPM) values including only proteome-validated sequences. The twelve selected venom proteins that we discuss herein further as dominant bee venom proteins are printed in bold in the colour code used for these proteins in this manuscript. Peptide names in white were not identified by our proteo-transcriptome data but are present in published data. For our new proteo-transcriptome data (A.), the green circles indicate venom proteins identified by proteo-transcriptomics, grey circles indicate transcriptome-only hits. White circles illustrate missing data. For published data the green X indicate major components identified in literature, red questions marks highlight missing/unclear data. Orange X highlight the “aculeatoxin” peptides (According to Robison et al. [29], melittin is also a member of the proposed aculeatoxin family, which is separately shown as part of the PBVPs)