Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72

Table 2 All PDB structures to date containing active μOR or Nb39, with inactive μOR for comparison

PDB	Species		Bound to		Ligand	Resolution	Source
	Mouse	Human	Nb39	G_i		(Å)
Active μOR
5C1M	•		•		BU72	2.1	[3]
6DDF	•			•	DAMGO	3.5	[45]
7SBF	•			•	PZM21	2.9	[46]
7SCG	•			•	FH210	3.0	[46]
7T2G	•			•	Mitragynine pseudoindoxyl	2.5	[47]
7T2H	•			•	Lofentanil	3.2	[47]
7U2K	•			•	C6 guano	3.3	[48]
7U2L	•			•	C5 guano	3.2	[48]
8EF5		•		•	Fentanyl	3.3	[49]
8EF6		•		•	Morphine	3.2	[49]
8EFB		•		•	Oliceridine	3.2	[49]
8EFL		•		•	SR-17018	3.2	[49]
8EFO		•		•	PZM21	2.8	[49]
8EFQ		•		•	DAMGO	3.3	[49]
8F7Q		•		•	β-endorphin	3.2	[50]
8F7R		•		•	Endomorphin-1	3.3	[50]
Active κOR
6B73	•		•		MP1104	3.1	[51]
7YIT		•	•		Nalfurafine	3.3	[52]
Inactive μOR
7UL4	•				Alvimopan	2.8	[53]

Species, binding partner and resolution are indicated. PDB entry 6DDE is omitted: 6DDF is a higher-resolution analysis of the same dataset

ISSN: 1741-7007