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Fig. 2 | BMC Biology

Fig. 2

From: Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism

Fig. 2

Transcriptomic divergence of hepatocyte revealed by cross-species comparison. A UMAP representation of four species comparison among human, monkey, mouse, and giant panda datasets of liver. Cell identity was in the right legend. B Violin plots indicating the numbers of UMI and genes detected in liver datasets of human, monkey, mouse, and giant panda. C Re-clustering of all hepatocyte clusters from (A) and circled by species. D GO enrichment analysis for DEGs of hepatocytes from monkey and giant panda. E Expression level of AMPK and TOR subunits in each hepatocyte cluster. F UMAP representations with nuclei colored by the expression level of essential genes. G Promoted or repressed metabolic signal pathways which were direct downstream targets of activated AMPK. H Expression level of genes involved in lysosome activity. I Potential non-canonical activation of AMPK

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BMC Biology

ISSN: 1741-7007

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