Fig. 2

Differential splicing is just as frequent as differential expression. A The number of significant genes for each comparison across analyses. B For each analysis, the fraction of genes tested that were deemed significant. C The fraction of differentially expressed genes that were also differentially spliced. D Within the genes that are both differentially expressed and spliced, we calculated the fraction of the gene expression that is contributed by differentially spliced transcripts. For each analysis, we extracted the median. E The number of differentially spliced genes as a fraction of the total number of genes either differentially spliced or expressed genes (total transcriptional signal). Across all panes, significance is defined as having an FDR-adjusted p-value of < 0.05. Medians are indicated for all plots