Fig. 1

HUVEC recruitment by iWJ-MSC-EV-containing agarose spots: partial spot image analysis (12 h). Quantification of HUVEC’s migration at the final time-point: A number of cells inside the spot, B maximum migration distance from the spot’s border, and C total area occupied by cells inside the spot. D Representative images (× 20) of the HUVEC’s recruitment in all conditions. Scale bar is 100 μm. Agarose spot’s border is represented as a yellow dotted line. Data from 4 independent experiments with 3 replicates/condition. The statistical differences are indicated for *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, by a Kruskal–Wallis test with a Dunn’s post hoc analysis