Fig. 3

A-to-I editing landscape in X. laevis tissues. A PCA plot based on gene expression values showing clear separation of gonad samples. B Transcript levels of ADAR enzymes in various adult tissues. The ADAR expression values are provided in Additional File 2. C Global editing index measured across all repeat families in various adult tissues. D Editing index for each individual repeat family in various adult tissues. Fourteen repeat families contained relatively few editing events and thus were grouped together for calculation of the index. E Hierarchical clustering of editing levels. Each row is a different editing site, while each column is a different adult tissue. F Many loci were targeted by ADARs in only a single adult tissue. Top: Heatmap depicting the editing rates of these tissue-specific sites. Bottom: Genomic locations of the tissue-specific sites. G Top 10 GO terms associated with ovary-specific and brain-specific editing sites. Dotted line indicates the p-value threshold of 0.05. ER refers to endoplasmic reticulum. H Comparison of editing events identified in oocytes with those identified in the ovary