Fig. 2
From: The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila
Analysis of the phenotype of adult DlattP-Dl-HA and DlattP-DlK2R-HA flies. A–G The phenotype of flies with one copy of DlattP-Dl-HA (B, F) and DlattP-DlK2R-HA (C, G) over the deficiency DlBSC850 (Df). Compare with the wildtype control, shown in A, D. In contrast to the wildtype and DlattP-Dl-HA/Df flies, the tarsal segments 4 and 3 are fused in DlattP-DlK2R-HA/Df flies.E, FDlattP-Dl-HA/Df flies show the typical haplo-insufficient wing vein broadening of Dl. The vein broadening is only slightly enhanced in DlattP-DlK2R-HA/Df flies. H, J The phenotype of flies homozygous for DlattP-Dl-HA resembles that of wildtype flies (compare with A, D). I, K In contrast, homozygous DlattP-DlK2R-HA displays enhanced broadening of the wing veins and nicks in the wing margin (I, arrowheads). Moreover, tarsal segments 1 and 2 are fused in addition to 3 and 4 (K, arrowheads). L–N The phenotype of DlattP-DlK2R-HA homozygous flies is suppressed if two additional copies of Notch are present