Fig. 6

Interactome of T. vaginalis ERMES components. The interactome was constructed based on coIP experiments and mass spectrometry (Additional file 4: Table S3). Large colored boxes indicate the baits that were used for the coIP complexes. CoIP proteins are linked with color-coded lines. Solid lines indicate significantly enriched proteins coIP with the bait (FDR 0.05, S = 1), and dotted lines indicate ERMES components that coIP under the threshold of significance. Proteins that coIP with more than a single bait are included, except selected proteins of interest that coIP with Porin2 and Mmm2a baits. AMP-CoA-lig, AMP CoA ligase; CHP, conserved hypothetical protein; EF-hand, EF-hand calcium-binding protein; MCP, mitochondrial carrier protein; MLF, myeloid leukemia factor; NTPase, P-loop containing nucleoside triphosphate hydrolase family protein; PK, protein kinase; PNP, purine nucleoside phosphorylase; PSP, protein serine phosphatase; Rab_u, unclassified Rab; βTub, β-tubulin