Fig. 2

Higher-order chromatin organization during Pre-B cell trans-differentiation. a Similarity scores between the replicates and different time points. Stratum adjusted correlation coefficient (SCC method) was used to quantify the similarity score by comparing HiC interaction matrix at 500 kb resolution. Reps, replicates. b Percentage of shared TAD boundaries between biological replicates and among samples from different time points. BioRep, comparison between biological replicates at each time point. DifTime, comparison between samples from different time points. c TAD structure at a region on chromosome 4—black triangles represent TADs, and yellow lines demarcate regions showing differences in TAD boundaries between time points. d Percentage of the genome that switches compartment (either A-to-B or B-to-A) during trans-differentiation. e The percentage of compartment change for significantly upregulated and downregulated genes (48h vs 0h). f The number of DEGs in different Fuzzy c-means clusters grouped by various compartments change. Unassigned: genes are not able to call compartments. g Examples of genes that are in B compartment but switch to A compartment. Gene expression tracks in green