Fig. 6

Correlation gene expression changes and tRNA epimutations. A Bubble plot showing the ontology term enrichment of genes associated with tRNAs. Enrichment calculated with χ.² test; top 10 results shown. The x-axis shows the log10(χ) for enrichment. The y-axis shows the ontology terms. Data from all lineages and all conditions were combined, i.e. N = 6. B Bubble plot of concordance (simultaneous and direction matched) or discordance (simultaneous but direction unmatched) of gene expression changes and tRNA epimutations in control condition (blue dots), cisplatin low dose (green dots) or cisplatin high dose (red dots). Two lineages per condition were used as biological replicates. The y-axis shows the association tests. The x-axis shows the log2(odds ratio) of gene expression changes to be associated with tRNA epimutation within each association. Odds ratios and p-values were calculated using Fisher’s exact test. C Stacked barplots representing the proportion of genes with inherited (left bar) of non-inherited (right bar) RNA expression changes targeted by tRNA epimutations in the control condition (left panel), cisplatin low-dose condition (middle panel) and cisplatin high-dose condition (right panel). Two lineages per condition were used as biological replicates. In blue, the percentage of genes with simultaneous inherited tRNA epimutations; in grey, the percentage of genes with simultaneous non-inherited tRNA epimutations; and in orange, the percentage of genes with non-simultaneous tRNA epimutations. Supporting data for the whole figure is available in the Excel file: “Additional file 25”