Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans

Table 1 Genes showing both a change in the expression level and a DNA mutation

Condition	Lineage	Gene (WB)	Gene	Gen. exp. chg	+ / −	Gen. mut	Mut. type
Low dose	L1	WBGene00019132	bath-19	2_10_16	+	16	Indel
Low dose	L1	WBGene00018024	F35A5.1	2_10_16	+	16	SNP
Low dose	L2	WBGene00012792	Y43D4A.6	20	+	20?	SNP
High dose	H2	WBGene00001839	hdl-1	18	−	18	SNP

Data were missing for DNA mutation identification at generations 18 and 20 for low-dose L2, but in the gene Y43D4A.6, the SNP appeared at generation 10 and up to generation 16; we thus assumed that it would also be observed in the subsequent generations if it is a true mutation. Supporting information for this table can be found in the Excel file: “Additional file 10”
The “ + / − ” column indicates if the observed change was overexpression ( +) or underexpression ( −)
WB WormBase identification number, Gen. exp chg. generations with gene expression change; Gen. mut. generations showing DNA mutation; Mut. type. type of mutation

ISSN: 1741-7007