Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans

Table 3 Comparison of odds of association between 22G-RNA or tRNA epimutations and gene expression changes

Condition	Association tested	X = 22G-RNAs	X = tRNAs	Odds ratio	p-value
Control	Genes with exp. change + simultaneous X epimutation	75	2	0.66	0.64
Control	Genes with exp. change only	912	16	0.66	0.64
Low dose	Genes with exp. change + simultaneous X epimutation	73	4	0.16	9.30e − 03
Low dose	Genes with exp. change only	936	8	0.16	9.30e − 03
High dose	Genes with exp. change + simultaneous X epimutation	65	6	0.10	2.96e − 04
High dose	Genes with exp. change only	851	8	0.10	2.96e − 04

Cells with p-value < 0.05 indicate the significantly increased odds of association for tRNAs compared to 22G-RNAs. Odds ratios and p-values were calculated with Fisher’s exact test. Data from the two lineages for each condition were combined (N = 2)

ISSN: 1741-7007