Fig. 5

ERβ shares ovarian cistrome with LRH-1. A Venn diagram comparing distribution and co-occurrence of ERE, GATA, and NR5A motifs in all identified ERβ-bound sequences. B Venn diagram representing the overlapping chromatin-binding sites between ERβ and LRH-1. C Enriched biological pathways, summarized by REVIGO, comparing genes located nearest to chromatin bound by both ERβ and LRH-1 or specifically bound by either ERβ or LRH-1. The size of the bubbles corresponds to the enrichment score (-log₁₀(p-value)). D Venn diagram comparing distribution and co-occurrence of ERE and NR5A motifs in the the sequences bound by both ERβ and LRH-1. E The distance between ERE and NR5A motifs in the sequences containing dual motifs and bound by both ERβ and LRH-1 (from D) plotted within +/- 200 bp. F, G Density plots representing motif occurrence within +/- 1500 bp distance of F all common ERβ and LRH-1 binding sites, and G all ERβ-binding sites. H Venn diagram comparing ERβ ChIP-seq with accessible chromatin (genes) using publicly available FAIRE-seq data [51] from granulosa cells during ovulatory stimulation. I, J ChIP enrichment and corresponding gene regulation (RNA-seq) of critical genes that require ERβ. All tracks are set to the same Y-axis height for the ChIP-seq and input