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Table 1 Ovarian genes that appear dependent on ERβ for their in vivo expression

From: Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1

Gene

Gene name

log2FC

ERβKO (FPKM)

WT (FPKM)

ERβ-binding site

Bhmt

betaine-homocysteine methyltransferase

-6,7

0,3

34,0

Intergenic

Mmel1

membrane metallo-endopeptidase-like 1

-5,1

0,3

9,1

-

Ssu2

ssu-2 homolog (C. elegans)

-4,2

0,3

6,2

-

Slc38a3

solute carrier family 38, member 3

-3,2

1,0

10,1

Intron 1

Lrp8

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

-3,1

1,5

13,4

Intron 1

Them5

thioesterase superfamily member 5

-2,3

0,4

2,2

-

Cabp1

calcium binding protein 1

-1,9

0,9

4,2

Intron 1

Tspan11

tetraspanin 11

-1,9

0,9

3,1

Intron 2

Lrp11

low density lipoprotein receptor-related protein 11

-1,6

1,9

5,8

Intron 1

Abca7

ATP-binding cassette, sub-family A (ABC1), member 7

-1,6

1,6

4,9

Exon

Stx11

syntaxin 11

-1,4

1,3

3,4

-

Adrb2

adrenergic receptor, beta 2

-1,3

1,3

3,0

-

Ctnna2

catenin (cadherin associated protein), alpha 2

-1,2

1,0

2,2

Intron 1

Nipal1

NIPA-like domain containing 1

-1,1

1,2

2,6

-

  1. Genes that are not expressed (< 2 FPKM per RNA-seq) in ERβKO ovary but expressed (> 2 FPKM and at least 2-fold more) in WT ovary, with high confidence of regulation across the individual samples (FDR < 0.0001). FPKM values represents average ovarian expressions (WT: n = 5 mice; ERβKO: n = 4 mice)