Table 2 Top downregulated ERβKO ovary genes with de facto ERβ and LRH-1 chromatin binding
From: Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
Gene | Gene Name | log2FC | ERβ location(s) | TSS (kb) | ERE | NR5A |
|---|---|---|---|---|---|---|
Slc38a3 | solute carrier family 38, member 3 | -3.2 | intron 4 | 9.1 | - | - |
Lrp8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -3.1 | intron 2 | 9.0 | - | + |
Cst8 | cystatin 8 (cystatin-related epididymal spermatogenic) | -2.3 | intron 2 | 2.8 | + | + |
Nrn1 | neuritin 1 | -2.3 | downstream genea | 224 | - | + |
Sgk1 | serum/glucocorticoid regulated kinase 1 | -2.1 | intergenic | -38 | - | + |
Gsg1l | GSG1-like | -2.1 | intron 2 | 113 | + | ×2 |
Dpysl4 | dihydropyrimidinase-like 4 | -2.1 | upstream geneb | -62 | + | + |
Cabp1 | calcium binding protein 1 | -1.9 | intron 1 | 2.7 | - | - |
Tspan11 | tetraspanin 11 | -1.9 | downstream genec | 94 | - | - |
Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | -1.8 | intergenic | -3.5 | - | + |
Fkbp5 | FK506 binding protein 5 | -1.7 | 1: intergenic | -22 | + | ×3 |
2: intron 3 | 54 | - | ×3 | |||
Dsc2 | desmocollin 2 | -1.7 | intron 1 | 0.7 | + | + |
Crybb1 | crystallin, beta B1 | -1.7 | intergenic | -1.4 | + | + |
Txndc2 | thioredoxin domain containing 2 (spermatozoa) | -1.6 | 1: upstream gened | -62 | - | ×3 |
2: intergenic | -5.3 | - | + | |||
Fbn2 | fibrillin 2 | -1.6 | intron 2 | 2.3 | + | + |
Lockd | lncRNA downstream of Cdkn1b | -1.6 | intergenic | 25 | - | ×2 |
Aif1l | allograft inflammatory factor 1-like | -1.5 | intron 2 | 4.5 | + | + |
Parvb | parvin, beta | -1.5 | intron 1 | 36 | - | + |
Tpst2 | protein-tyrosine sulfotransferase 2 | -1.4 | intron 1 | 22 | + | ×2 |
Ddah1 | dimethylarginine dimethylaminohydrolase 1 | -1.3 | intron 1 | 47 | + | - |
Mrap | melanocortin 2 receptor accessory protein | -1.3 | intergenic | -2.4 | - | + |
Ctnna2 | catenin (cadherin associated protein), alpha 2 | -1.2 | 1: intergenic | -192 | ×2 | - |
2: intron 1 | 71 | + | + | |||
Hao2 | hydroxyacid oxidase 2 | -1.1 | 1: intergenic | -39 | - | + |
2: intron 1 | 2.6 | - | - | |||
Gpr37 | G protein-coupled receptor 37 | -1.1 | intergenic | 239 | - | ×3 |
Ttyh2 | tweety family member 2 | -1.0 | intron 3 | 16 | - | ×2 |
Fzd1 | frizzled class receptor 1 | -1.0 | intergenic | 262 | - | + |
Nek6 | NIMA (never in mitosis gene a)-related expressed kinase 6 | -1.0 | intergenic | -13 | - | - |
Slc6a6 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | -1.0 | intergenic | -37 | + | - |