Table 1 Effect of BBR on FtfLs from different strains. The inhibition of BBR on FtfLs from S. faecalis, L. reuteri, L. acidophilus, and L. fermentum is not determined due to non-detectable enzymatic activity; “ns” means no significance, representing that FtfL from this strain is not inhibited by BBR
From: Identification of FtfL as a novel target of berberine in intestinal bacteria
Strain | ftfl Gene ID | Inhibited by BBR (IC50) |
|---|---|---|
CRC pathogens | ||
Peptostreptococcus anaerobius | 79,842,341 | 62.3 ± 10 μM |
Fusobacterium nucleatum | 45,633,862 | 106.2 ± 27.0 μM |
Clostridium symbiosum | 57,969,199 | 128.9 ± 17.1 μM |
Lactococcus lactis | 69,713,002 | 118.1 ± 18.5 μM |
Streptococcus faecalis | 60,894,021 | / |
Colitis pathogens | ||
Bacteroides fragilis | 66,328,797 | 105.1 ± 69.8 μM |
Clostridioides difficile | 66,353,223 | 158.0 ± 68.7 μM |
Vibrio cholerae | 69,721,326 | 129.6 ± 12.3 μM |
Clostridium perfringens | 69,450,453 | 104.9 ± 3.15 μM |
Nonpathogenic bacteria | ||
Clostridium ljungdahlii | 45,181,033 | 83.8 ± 10 μM |
Clostridium sporogenes | 69,424,169 | ns |
Parabacteroides distasonis | 57,237,971 | > 200.0 μM |
Ruminococcus obeum | 15,206,023 | 100.1 ± 3.26 μM |
Probiotics | ||
Lactobacillus plantarum | 57,025,392 | > 200.0 μM |
Lactobacillus reuteri | 69,707,752 | / |
Lactobacillus acidophilus | 56,943,130 | / |
Lactobacillus fermentum | 12,456,081 | / |