Fig. 2
From: Dysregulation of innate immune signaling in animal models of spinal muscular atrophy
Proteins involved in Drosophila humoral and melanization defense responses are elevated in Smn mutant proteomes. A Gene Ontology (GO) analysis of protein differences in V72G. Adjusted p-values (p.adjust) and number of genes per GO term (Count) are shown at right, which is used to compute a combined score. B Heat maps of select protein abundance differences from genes within the melanization defense response GO category, known immune-induced peptides, as well as for the NF-kB transcription factors dorsal-related immunity factor (Dif) and dorsal (dl). C, D Heatmap illustrations of TMT-MS data from V72G mutants. Log2-fold change (log2FC) values (mutant/control) for differentially expressed proteins are illustrated within the context of the Humoral Immune Response pathway (panel C, Wikipathways, WP3660) or the Melanization Cascade pathway (panel D) and shaded according to their respective keys