- Open Access
Host-parasite relationships in the genome
© Brookfield; licensee BioMed Central Ltd. 2011
- Received: 26 September 2011
- Accepted: 6 October 2011
- Published: 10 October 2011
Transposable elements are best interpreted as genomic parasites, proliferating in genomes through their over-replication relative to the rest of the genome. A new study examining correlations across Drosophila species between transposable element numbers and rates of host evolution has brought into focus one of the most complex questions in transposable element biology-what it is that determines the proportion of the genome that is transposable elements.
See research article: http://0-www.biomedcentral.com.brum.beds.ac.uk/1471-2148/11/258/
- Transposable Element
- Amino Acid Change
- Adaptive Evolution
- Codon Usage Bias
- Optimal Phenotype
Work on mobile DNAs in our group is funded by the BBSRC.
- Werren JH: Selfish genetic elements, genetic conflict and evolutionary innovation. Proc Natl Acad Sci USA. 2011, 108: 10863-10870. 10.1073/pnas.1102343108.PubMed CentralView ArticlePubMedGoogle Scholar
- González J, Lenkov K, Lipatov M, MacPherson M, Petrov DA: High rate of recent transposable element-induced adaptation in Drosophila melanogaster. PLoS Biol. 2008, 6: e251-10.1371/journal.pbio.0060251.PubMed CentralView ArticlePubMedGoogle Scholar
- Lowe CB, Bejerano G, Haussler D: Thousands of human mobile element fragments undergo strong purifying selection near developmental genes. Proc Natl Acad Sci USA. 2007, 104: 8005-8010. 10.1073/pnas.0611223104.PubMed CentralView ArticlePubMedGoogle Scholar
- Le Rouzic A, Boutin TS, Capy P: Long-term evolution of transposable elements. Proc Natl Acad Sci USA. 2007, 104: 19375-19380. 10.1073/pnas.0705238104.PubMed CentralView ArticlePubMedGoogle Scholar
- Venner S, Feschotte C, Biemont C: Dynamics of transposable elements: towards a community ecology of the genome. Trends Genet. 2009, 25: 317-323. 10.1016/j.tig.2009.05.003.PubMed CentralView ArticlePubMedGoogle Scholar
- Castillo DM, Mell JC, Box KS, Blumenstiel JP: Molecular evolution under increasing transposable element burden in Drosophila: A speed limit on the evolutionary arms race. BMC Evol Biol. 2011, 11: 258-10.1186/1471-2148-11-258.PubMed CentralView ArticlePubMedGoogle Scholar
- Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, Sachidanandam R, Hannon GJ: Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell. 2007, 128: 1089-1103. 10.1016/j.cell.2007.01.043.View ArticlePubMedGoogle Scholar
- Lu J, Clark AG: Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in Drosophila. Genome Res. 2010, 20: 212-227. 10.1101/gr.095406.109.PubMed CentralView ArticlePubMedGoogle Scholar
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